Last update Oct. 15, 2016

Cefpirome Sulfate

Very Low Risk

Safe. Compatible. Minimal risk for breastfeeding and infant.

Fourth-generation cephalosporins for injection or parenteral administration.

At latest update no published data on excretion into breast milk were found.

Most cephalosporins are excreted into milk in insignificant amounts from a therapeutic point of view without reported complications in infants.

Cephalosporins are widely used in the Pediatric practice with a good tolerance, even in the neonatal period, so it is very unlikely that in small amounts through milk would be a cause of problems in the infant.

Be aware of the possibility of false negative results of cultures in febrile infants whose mothers are taking antibiotics as well as the possibility of gastroenteritis (Ito 1993) by altering the intestinal flora.

Alternatives

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Other names

Cefpirome Sulfate in other languages or writings:

Group

Cefpirome Sulfate belongs to this group or family:

Tradenames

Main tradenames from several countries containing Cefpirome Sulfate in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. Baja - Poor %
Molecular weight 613 daltons
Protein Binding 10 %
VD 0.3 l/Kg
Tmax 1.5 hours
T½ 2.3 hours

References

  1. Ito S, Blajchman A, Stephenson M, Eliopoulos C, Koren G. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993 May;168(5):1393-9. Abstract
  2. Strenkoski LC, Nix DE. Cefpirome clinical pharmacokinetics. Clin Pharmacokinet. 1993 Abstract
  3. Kavi J, Andrews JM, Ashby JP, Hillman G, Wise R. Pharmacokinetics and tissue penetration of cefpirome, a new cephalosporin. J Antimicrob Chemother. 1988 Abstract

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