Last update Oct. 15, 2016

Cefotaxime Sodium

Very Low Risk

Safe. Compatible. Minimal risk for breastfeeding and infant.

Third-generation cephalosporin for injection or parenteral administration.

Like most cephalosporins for which data are available, excretion occurs in breast milk in very small or undetectable amount and it is clinically insignificant (Kafetzis 1980-1981, Takase 1982, Cho 1982, Yasuda 1982, Matsuda 1984).

Cephalosporins are widely used in the Pediatric practice with a good tolerance, even in the neonatal period, so it is very unlikely that in small amounts through milk would be a cause of problems in the infant.

Be aware of the possibility of false negative results of cultures in febrile infants whose mothers are taking antibiotics as well as the possibility of gastroenteritis (Ito 1993) by altering the intestinal flora.

Tne American Academy of Pediatrics classifies it as a medication usually compatible with breastfeeding.

Alternatives

We do not have alternatives for Cefotaxime Sodium since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Other names

Cefotaxime Sodium in other languages or writings:

Group

Cefotaxime Sodium belongs to this group or family:

Tradenames

Main tradenames from several countries containing Cefotaxime Sodium in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. Baja - Poor %
Molecular weight 477 daltons
Protein Binding 40 %
VD 0.2 - 0.3 l/Kg
Tmax 0.5 hours
T½ 0.7 hours
M/P ratio 0.2 -
Theoretical Dose 0.05 mg/Kg/d
Relative Dose 0.14 %
Ped.Relat.Dose 0.05 %

References

  1. van Wattum JJ, Leferink TM, Wilffert B, Ter Horst PGJ. Antibiotics and lactation: An overview of relative infant doses and a systematic assessment of clinical studies. Basic Clin Pharmacol Toxicol. 2019 Jan;124(1):5-17. Abstract
  2. Rowe H, Baker T, Hale TW. Maternal medication, drug use, and breastfeeding. Pediatr Clin North Am. 2013 Feb;60(1):275-94. Abstract
  3. Bar-Oz B, Bulkowstein M, Benyamini L, Greenberg R, Soriano I, Zimmerman D, Bortnik O, Berkovitch M. Use of antibiotic and analgesic drugs during lactation. Drug Saf. 2003 Abstract
  4. AAP - American Academy of Pediatrics Committee on Drugs. Transfer of drugs and other chemicals into human milk. Pediatrics. 2001 Sep;108(3):776-89. Abstract Full text (link to original source) Full text (in our servers)
  5. Scott A, Forsyth S. Breast feeding and antibiotics. Mod Midwife. 1996 Abstract
  6. Ito S, Blajchman A, Stephenson M, Eliopoulos C, Koren G. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993 May;168(5):1393-9. Abstract
  7. Fulton B, Moore LL. Antiinfectives in breastmilk. Part I: Penicillins and cephalosporins. J Hum Lact. 1992 Abstract
  8. Matsuda S. Transfer of antibiotics into maternal milk. Biol Res Pregnancy Perinatol. 1984;5(2):57-60. Abstract
  9. Cho N, Fukunaga K, Kunii K. [A study of clinical application of cefotaxime in the perinatal period]. Jpn J Antibiot. 1982 Abstract
  10. Takase Z, Fujiwara M, Kohmoto Y, Seto M, Shirafuji H. [Study of cefotaxime in the perinatal period]. Jpn J Antibiot. 1982 Abstract
  11. Yasuda J, Yamamoto T, Ito M, Honjo H, Okada H, Kanao M. [Fundamental and clinical studies on cefotaxime in the perinatal period]. Jpn J Antibiot. 1982 Abstract
  12. Kafetzis DA, Siafas CA, Georgakopoulos PA, Papadatos CJ. Passage of cephalosporins and amoxicillin into the breast milk. Acta Paediatr Scand. 1981 Abstract
  13. Kafetzis DA, Lazarides CV, Siafas CA, Georgakopoulos PA, Papadatos CJ. Transfer of cefotaxime in human milk and from mother to foetus. J Antimicrob Chemother. 1980 Abstract

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