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An antiprotozoal and antibacterial (anaerobic bacteria). Indicated in urogenital trichomoniasis, non-specific vaginitis, giardiasis, intestinal and hepatic amebiasis, acute ulcerative gingivitis and prophylaxis of postoperative infections by anaerobic bacteria.
Administered orally or intravenously in a single or daily dose for 3 to 6 days according to pathology.
It is excreted in breastmilk in clinically insignificant amounts (Evaldson 1985, Männistö 1983, Wood 1982), much lower than the dose prescribed to infants.
Its use is authorized in infants from one month old.
Some authors recommend waiting 3 days before breastfeeding again following administration (CDC 2010, Evaldson 1985). In the meantime, express and discard breastmilk regularly.
The possibility of transient gastroenteritis due to altered intestinal flora in infants whose mothers take antibiotics should be taken into account (Ito 1993).
It has very little plasma absorption when used topically, as a cream or vaginal ovules, so the amount excreted in milk is expected to be even less than following systemic administration.