Last update Jan. 15, 2020



Safe substance and/or breastfeeding is the best option.

An antiprotozoal and antibacterial (anaerobic bacteria). Indicated in urogenital trichomoniasis, non-specific vaginitis, giardiasis, intestinal and hepatic amebiasis, acute ulcerative gingivitis and prophylaxis of postoperative infections by anaerobic bacteria.
Administered orally or intravenously in a single or daily dose for 3 to 6 days according to pathology.

It is excreted in breastmilk in clinically insignificant amounts (Evaldson 1985, Männistö 1983, Wood 1982), much lower than the dose prescribed to infants.

Its use is authorized in infants from one month old.

Some authors recommend waiting 3 days before breastfeeding again following administration (CDC 2010, Evaldson 1985). In the meantime, express and discard breastmilk regularly.

The possibility of transient gastroenteritis due to altered intestinal flora in infants whose mothers take antibiotics should be taken into account (Ito 1993).

It has very little plasma absorption when used topically, as a cream or vaginal ovules, so the amount excreted in milk is expected to be even less than following systemic administration.


Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

1-[2-(Ethylsulphonyl)ethyl]-2-methyl-5-nitroimidazole is Tinidazole in Chemical name.

Is written in other languages:


1-[2-(Ethylsulphonyl)ethyl]-2-methyl-5-nitroimidazole belongs to these groups or families:


Main tradenames from several countries containing 1-[2-(Ethylsulphonyl)ethyl]-2-methyl-5-nitroimidazole in its composition:


Variable Value Unit
Oral Bioavail. 100 %
Molecular weight 247 daltons
Protein Binding 12 %
VD 0.8 l/Kg
Tmax 2 hours
12 - 14 hours
M/P ratio 1.3 -
Theoretical Dose 0.87 - 1.91 mg/Kg/d
Relative Dose 2.6 - 5.7 %
Ped.Relat.Dose 1.2 - 3.8 %


  1. Workowski KA, Bachmann LH, Chan PA, Johnston CM, Muzny CA, Park I, Reno H, Zenilman JM, Bolan GA. Sexually Transmitted Infections Treatment Guidelines, 2021. MMWR Recomm Rep. 2021 Jul 23;70(4):1-187. Abstract Full text (link to original source)
  2. CDC - Workowski KA, Berman S; Centers for Disease Control and Prevention (CDC). Sexually transmitted diseases treatment guidelines, 2010. MMWR Recomm Rep. 2010 Abstract Full text (link to original source) Full text (in our servers)
  3. Ito S, Blajchman A, Stephenson M, Eliopoulos C, Koren G. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993 May;168(5):1393-9. Abstract
  4. Roe FJ. Safety of nitroimidazoles. Scand J Infect Dis Suppl. 1985 Abstract
  5. Evaldson GR, Lindgren S, Nord CE, Rane AT. Tinidazole milk excretion and pharmacokinetics in lactating women. Br J Clin Pharmacol. 1985 Abstract Full text (link to original source) Full text (in our servers)
  6. Männistö PT, Karhunen M, Koskela O, Suikkari AM, Mattila J, Haataja H. Concentrations of tinidazole in breast milk. Acta Pharmacol Toxicol (Copenh). 1983 Abstract
  7. Wood BA, Faulkner JK, Monro AM. The pharmacokinetics, metabolism and tissue distribution of tinidazole. J Antimicrob Chemother. 1982 Abstract
  8. Chaikin P, Alton KB, Sampson C, Weintraub HS. Pharmacokinetics of tinidazole in male and female subjects. J Clin Pharmacol. 1982 Abstract
  9. Andersson KE. Pharmacokinetics of nitroimidazoles. Spectrum of adverse reactions. Scand J Infect Dis Suppl. 1981 Abstract
  10. Wood BA, Monro AM. Pharmacokinetics of tinidazole and metronidazole in women after single large oral doses. Br J Vener Dis. 1975 Abstract Full text (link to original source) Full text (in our servers)

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e-lactancia is a resource recommended by El Parto Es Nuestro of Spain

Would you like to recommend the use of e-lactancia? Write to us at corporate mail of APILAM