Last update Oct. 30, 2023

Альвимопан

Likely Compatibility

Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.

Alvimopan is an opioid antagonist used to reduce the healing time of postoperative ileus of the upper or lower gastrointestinal tract following surgical procedures involving bowel resection with primary anastomosis. Oral administration twice daily for 7 days after surgery.

At the time of the last update, we found no published data on its excretion in breast milk.

Its large volume of distribution, high percentage of binding to plasma proteins and moderately high molecular weight make it unlikely to pass into breast milk in clinically significant quantities.

Its very low oral bioavailability makes it difficult to pass into infant plasma from ingested breast milk.

Alternatives

We do not have alternatives for Альвимопан.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Альвимопан is Alvimopan in Cyrillic.

Is written in other languages:

Group

Альвимопан belongs to this group or family:

Tradenames

Main tradenames from several countries containing Альвимопан in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 6 %
Molecular weight 425 daltons
Protein Binding 80 - 94 %
VD 0.42 (0.3 - 0.6) l/Kg
pKa 3.71 -
Tmax 2 hours
10 - 18 hours

References

  1. FDA. Alvimopan (Entereg). Drug Summary. 2008 Full text (link to original source) Full text (in our servers)

Total visits

171

Help us improve this entry

How to cite this entry

Do you need more information or did not found what you were looking for?

   Write us at elactancia.org@gmail.com

e-lactancia is a resource recommended by El Parto Es Nuestro of Spain

Would you like to recommend the use of e-lactancia? Write to us at corporate mail of APILAM