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Alvimopan is an opioid antagonist used to reduce the healing time of postoperative ileus of the upper or lower gastrointestinal tract following surgical procedures involving bowel resection with primary anastomosis. Oral administration twice daily for 7 days after surgery.
At the time of the last update, we found no published data on its excretion in breast milk.
Its large volume of distribution, high percentage of binding to plasma proteins and moderately high molecular weight make it unlikely to pass into breast milk in clinically significant quantities.
Its very low oral bioavailability makes it difficult to pass into infant plasma from ingested breast milk.