Last update: March 22, 2018

Guaranine

Low Risk for breastfeeding


Moderately safe. Probably compatible.
Mild risk possible. Follow up recommended.
Read the Comment.

Trimethylxanthine component which is present in many compounds like decongestant or pain relief drugs (50 to 100 mg per unit) .

It is also present in many infusion beverages (coffee, tea, mate, guarana) and other drinks with allegedly energizing properties. See also Coffee, Caffeine (beverages).

At a dose higher than 300 mg a-day may induce nervousness and irritability in the infant. Intravenous high doses used to treat post-epidural anesthesia headache within 2-3 days after delivery, before mature breast milk comes, are compatible with breastfeeding.

High doses used Intravenously to treat headache related to epidural should be regarded as compatible with breastfeeding only in the 2-3 days before milk comes in.

Elimination period may last from few hours in adults, to 3-4 days in the newborn infant.

American Academy of Pediatrics: Maternal Medication Usually Compatible With Breastfeeding.


See below the information of this related product:

Alternatives

We do not have alternatives for Guaranine.

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Guaranine is also known as Caffeine. Here it is a list of alternative known names::


Guaranine in other languages or writings:

Group

Guaranine belongs to this group or family:

Tradenames

Main tradenames from several countries containing Guaranine in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 100 %
Molecular weight 194 daltons
Protein Binding 36 %
VD 0,6 l/Kg
Tmax 0,5 - 2 hours
T1/2 3 - 7 hours
M/P ratio 0,8 -
Theoretical Dose 0,4 mg/Kg/d
Relative Dose 4 - 18 %
Relat.Ped.Dose 4 - 8 %

References

  1. Bordini CA, Roesler C, Carvalho Dde S, Macedo DD, Piovesan É, Melhado EM, Dach F, Kowacs F, Silva Júnior HM, Souza JA, Maciel JA Jr, Carvalho JJ, Speciali JG, Barea LM, Queiroz LP, Ciciarelli MC, Valença MM, Lima MM, Vincent MB. Recommendations for the treatment of migraine attacks - a Brazilian consensus. Arq Neuropsiquiatr. 2016 Abstract Full text (link to original source) Full text (in our servers)
  2. Yurcheshen M, Seehuus M, Pigeon W. Updates on Nutraceutical Sleep Therapeutics and Investigational Research. Evid Based Complement Alternat Med. 2015 Abstract Full text (link to original source) Full text (in our servers)
  3. Davanzo R, Bua J, Paloni G, Facchina G. Breastfeeding and migraine drugs. Eur J Clin Pharmacol. 2014 Abstract
  4. Rowe H, Baker T, Hale TW. Maternal medication, drug use, and breastfeeding. Pediatr Clin North Am. 2013 Feb;60(1):275-94. Abstract
  5. Escuder-Vieco D, Garcia-Algar O, Pichini S, Pacifici R, García-Lara NR, Pallás-Alonso CR. Validation of a Screening Questionnaire for a Human Milk Bank to Determine the Presence of Illegal Drugs, Nicotine, and Caffeine. J Pediatr. 2013 Abstract
  6. McGuinness N, Cording V. Raynaud's phenomenon of the nipple associated with labetalol use. J Hum Lact. 2013 Abstract Full text (link to original source) Full text (in our servers)
  7. Pituch A, Hamułka J, Wawrzyniak A, Zdanowski K. [Assessment of stimulant use especially caffeine intake in selected group of the breastfeeding women]. Rocz Panstw Zakl Hig. 2012 Abstract
  8. Santos IS, Matijasevich A, Domingues MR. Maternal caffeine consumption and infant nighttime waking: prospective cohort study. Pediatrics. 2012 Abstract Full text (link to original source) Full text (in our servers)
  9. Martín I, López-Vílchez MA, Mur A, García-Algar O, Rossi S, Marchei E, Pichini S. Neonatal withdrawal syndrome after chronic maternal drinking of mate. Ther Drug Monit. 2007 Abstract
  10. McNamara PJ, Abbassi M. Neonatal exposure to drugs in breast milk. Pharm Res. 2004 Abstract
  11. AAP - American Academy of Pediatrics Committee on Drugs. Transfer of drugs and other chemicals into human milk. Pediatrics. 2001 Sep;108(3):776-89. Abstract Full text (link to original source) Full text (in our servers)
  12. Mitchell JL. Use of cough and cold preparations during breastfeeding. J Hum Lact. 1999 Abstract
  13. Barone JJ, Roberts HR. Caffeine consumption. Food Chem Toxicol. 1996 Abstract
  14. Oo CY, Burgio DE, Kuhn RC, Desai N, McNamara PJ. Pharmacokinetics of caffeine and its demethylated metabolites in lactation: predictions of milk to serum concentration ratios. Pharm Res. 1995 Abstract
  15. Blanchard J, Weber CW, Shearer LE. Methylxanthine levels in breast milk of lactating women of different ethnic and socioeconomic classes. Biopharm Drug Dispos. 1992 Abstract
  16. Fulton B. The galactopharmacopedia. Recreational drug use in the breastfeeding mother. Part 2: Licit drugs. J Hum Lact. 1990 Abstract
  17. Muñoz LM, Lönnerdal B, Keen CL, Dewey KG. Coffee consumption as a factor in iron deficiency anemia among pregnant women and their infants in Costa Rica. Am J Clin Nutr. 1988 Abstract Full text (link to original source) Full text (in our servers)
  18. Stavchansky S, Combs A, Sagraves R, Delgado M, Joshi A. Pharmacokinetics of caffeine in breast milk and plasma after single oral administration of caffeine to lactating mothers. Biopharm Drug Dispos. 1988 Abstract
  19. Ryu JE. Effect of maternal caffeine consumption on heart rate and sleep time of breast-fed infants. Dev Pharmacol Ther. 1985 Abstract
  20. Bucher HU, Gautschi K. [Detection of caffeine, theophylline and theobromine in the umbilical cord blood and breast milk]. Helv Paediatr Acta. 1985 Abstract
  21. Ryu JE. Caffeine in human milk and in serum of breast-fed infants. Dev Pharmacol Ther. 1985 Abstract
  22. Berlin CM Jr, Denson HM, Daniel CH, Ward RM. Disposition of dietary caffeine in milk, saliva, and plasma of lactating women. Pediatrics. 1984 Abstract
  23. Hildebrandt R, Gundert-Remy U. Lack of pharmacological active saliva levels of caffeine in breast-fed infants. Pediatr Pharmacol (New York). 1983 Abstract
  24. Bailey DN, Weibert RT, Naylor AJ, Shaw RF. A study of salicylate and caffeine excretion in the breast milk of two nursing mothers. J Anal Toxicol. 1982 Abstract
  25. Findlay JW, DeAngelis RL, Kearney MF, Welch RM, Findlay JM. Analgesic drugs in breast milk and plasma. Clin Pharmacol Ther. 1981 Abstract
  26. Tyrala EE, Dodson WE. Caffeine secretion into breast milk. Arch Dis Child. 1979 Abstract Full text (link to original source) Full text (in our servers)
  27. Rivera-calimlim L. Drugs in breast milk. Drug Ther (NY). 1977 Abstract

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