Last update: March 14, 2019


Low Risk probable for breastfeeding

Moderately safe.
Mild risk possible. Follow up recommended.
Read the Comment.

Infant intake after usual daily consumption of the mother is lower than usual recommended dose for neonatal apnea treatment.

Elimination-time period may last from few hours in adults, to 3-4 days in the newborn infant.

At higher dose (more than 300 mg per day) caffeine may induce irritability, tremor and insomnia in the infant. However, some infants may develop irritability at a lower dose; in those cases the mother should decide appropriate coffee intake. Some studies have failed to show harmful effect among infants whose mothers were strong coffee consumers even during pregnancy.

Daily intake as high as 1 liter or more has been associated to anemia and iron deficiency in mothers and breastfed infants. Also, has been related to the Raynaud's phenomenon in the nipple of nursing women.

Mean Caffeine content: 1 coffee cup: 100 mg, 1 black tea cup: 80 mg, 1 green tea cup: 50 mg, 1 liter of cola & soda and energizers beverages 100 to 340 mg.

See also Caffeine as medication.

The American Academy of Pediatrics rates it compatible with breastfeeding.

See below the information of this related product:


We do not have alternatives for Coffee.

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Coffee is also known as

Coffee in other languages or writings:


Main tradenames from several countries containing Coffee in its composition:


Variable Value Unit
Bioavailability 100 %
Molecular weight 194 daltons
Protein Binding 36 %
VD 0,6 l/Kg
Tmax 1 hours
T1/2 3 - 7 hours
M/P ratio 0,5 - 0,8 -
Theoretical Dose 0,4 mg/Kg/d
Relative Dose 4 - 18 %
Relat.Ped.Dose 4 - 8 %


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  2. Rowe H, Baker T, Hale TW. Maternal medication, drug use, and breastfeeding. Pediatr Clin North Am. 2013 Feb;60(1):275-94. Abstract
  3. McGuinness N, Cording V. Raynaud's phenomenon of the nipple associated with labetalol use. J Hum Lact. 2013 Abstract Full text (link to original source) Full text (in our servers)
  4. Escuder-Vieco D, Garcia-Algar O, Pichini S, Pacifici R, García-Lara NR, Pallás-Alonso CR. Validation of a Screening Questionnaire for a Human Milk Bank to Determine the Presence of Illegal Drugs, Nicotine, and Caffeine. J Pediatr. 2013 Abstract
  5. Pituch A, Hamułka J, Wawrzyniak A, Zdanowski K. [Assessment of stimulant use especially caffeine intake in selected group of the breastfeeding women]. Rocz Panstw Zakl Hig. 2012 Abstract
  6. Santos IS, Matijasevich A, Domingues MR. Maternal caffeine consumption and infant nighttime waking: prospective cohort study. Pediatrics. 2012 Abstract Full text (link to original source) Full text (in our servers)
  7. Rebhan B, Kohlhuber M, Schwegler U, Koletzko B, Fromme H. [Smoking, alcohol and caffeine consumption of mothers before, during and after pregnancy--results of the study 'breast-feeding habits in Bavaria']. Gesundheitswesen. 2009 Abstract
  8. Martín I, López-Vílchez MA, Mur A, García-Algar O, Rossi S, Marchei E, Pichini S. Neonatal withdrawal syndrome after chronic maternal drinking of mate. Ther Drug Monit. 2007 Abstract
  9. McNamara PJ, Abbassi M. Neonatal exposure to drugs in breast milk. Pharm Res. 2004 Abstract
  10. AAP - American Academy of Pediatrics Committee on Drugs. Transfer of drugs and other chemicals into human milk. Pediatrics. 2001 Sep;108(3):776-89. Abstract Full text (link to original source) Full text (in our servers)
  11. Nice FJ, Snyder JL, Kotansky BC. Breastfeeding and over-the-counter medications. J Hum Lact. 2000 Abstract
  12. Barone JJ, Roberts HR. Caffeine consumption. Food Chem Toxicol. 1996 Abstract
  13. Oo CY, Burgio DE, Kuhn RC, Desai N, McNamara PJ. Pharmacokinetics of caffeine and its demethylated metabolites in lactation: predictions of milk to serum concentration ratios. Pharm Res. 1995 Abstract
  14. Blanchard J, Weber CW, Shearer LE. Methylxanthine levels in breast milk of lactating women of different ethnic and socioeconomic classes. Biopharm Drug Dispos. 1992 Abstract
  15. Fulton B. The galactopharmacopedia. Recreational drug use in the breastfeeding mother. Part 2: Licit drugs. J Hum Lact. 1990 Abstract
  16. Stavchansky S, Combs A, Sagraves R, Delgado M, Joshi A. Pharmacokinetics of caffeine in breast milk and plasma after single oral administration of caffeine to lactating mothers. Biopharm Drug Dispos. 1988 Abstract
  17. Muñoz LM, Lönnerdal B, Keen CL, Dewey KG. Coffee consumption as a factor in iron deficiency anemia among pregnant women and their infants in Costa Rica. Am J Clin Nutr. 1988 Abstract Full text (link to original source) Full text (in our servers)
  18. Ryu JE. Caffeine in human milk and in serum of breast-fed infants. Dev Pharmacol Ther. 1985 Abstract
  19. Ryu JE. Effect of maternal caffeine consumption on heart rate and sleep time of breast-fed infants. Dev Pharmacol Ther. 1985 Abstract
  20. Bucher HU, Gautschi K. [Detection of caffeine, theophylline and theobromine in the umbilical cord blood and breast milk]. Helv Paediatr Acta. 1985 Abstract
  21. Berlin CM Jr, Denson HM, Daniel CH, Ward RM. Disposition of dietary caffeine in milk, saliva, and plasma of lactating women. Pediatrics. 1984 Abstract
  22. Hildebrandt R, Gundert-Remy U. Lack of pharmacological active saliva levels of caffeine in breast-fed infants. Pediatr Pharmacol (New York). 1983 Abstract
  23. Bailey DN, Weibert RT, Naylor AJ, Shaw RF. A study of salicylate and caffeine excretion in the breast milk of two nursing mothers. J Anal Toxicol. 1982 Abstract
  24. Findlay JW, DeAngelis RL, Kearney MF, Welch RM, Findlay JM. Analgesic drugs in breast milk and plasma. Clin Pharmacol Ther. 1981 Abstract
  25. Tyrala EE, Dodson WE. Caffeine secretion into breast milk. Arch Dis Child. 1979 Abstract Full text (link to original source) Full text (in our servers)
  26. Rivera-calimlim L. Drugs in breast milk. Drug Ther (NY). 1977 Abstract

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