Last update: Jan. 15, 2019

C02DC01; D11AX01

Very Low Risk for breastfeeding

Safe. Compatible.
Minimal risk for breastfeeding and infant.

An antihypertensive agent indicated in severe arterial hypertension.
Oral administration of 5 to 40mg daily in one or two doses, with the possibility of reaching 100mg daily.
Low doses of oral Minoxidil, from 0.5 to 2.5 mg daily, are being used to treat alopecia in women (Sinclair 2018, Perera 2017).

It is excreted in breastmilk in clinically insignificant amounts and no problems have been observed in an infant whose mother was taking it at an antihypertensive dose of 7.5 to 10 mg per day (Valdivieso 1985). The highest relative dose (RD) (5%) was obtained at the time of taking the medication, decreasing RD at three hours to 1.2%, at six hours to 0.3% and at nine hours to 0.1%.

You can therefore minimize the risk by avoiding breastfeeding at the time of taking the medication, which is when the levels in milk are higher.

The low doses that are prescribed for the treatment of alopecia pose few problems for breastfeeding.

American Academy of Pediatrics: it is a medication which is usually compatible with breastfeeding (Malachias 2016, AAP 2001). Some authors consider it safe in the case of breastfeeding older infants (Anderson 2018).

There are no published reports with antihypertensive doses greater than 10 mg per day, so in these cases, safer known alternatives may be preferable, especially in the neonatal period and in case of prematurity (Anderson 2018).

See below the information of this related product:


Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

C02DC01; D11AX01 is Minoxidil in ATC Code/s.

Is written in other languages:


Main tradenames from several countries containing C02DC01; D11AX01 in its composition:


Variable Value Unit
Oral Bioavail. 90 - 95 %
Molecular weight 209 daltons
Protein Binding 0 %
pKa 4,6 -
Tmax 1 hours
T1/2 4,2 hours
M/P ratio 0,65 - 1 -
Theoretical Dose 0,0001 - 0,006 mg/Kg/d
Relative Dose 0,1 - 5,0 %


  1. Anderson PO. Treating Hypertension During Breastfeeding. Breastfeed Med. 2018 Abstract
  2. Sinclair RD. Female pattern hair loss: a pilot study investigating combination therapy with low-dose oral minoxidil and spironolactone. Int J Dermatol. 2018 Abstract
  3. Perera E, Sinclair R. Treatment of chronic telogen effluvium with oral minoxidil: A retrospective study. F1000Res. 2017 Abstract
  4. Malachias MV, Figueiredo CE, Sass N, Antonello IC, Torloni MR, Bortolotto MRF L. 7th Brazilian Guideline of Arterial Hypertension: Chapter 9 - Arterial Hypertension in pregnancy Arq Bras Cardiol. 2016 Abstract Full text (link to original source) Full text (in our servers)
  5. Pfizer. Minoxidil (Loniten). Ficha técnica. 2015 Full text (in our servers)
  6. Pfizer. Minoxidil (Loniten). Drug Summary. 2015 Full text (in our servers)
  7. AAP - American Academy of Pediatrics Committee on Drugs. Transfer of drugs and other chemicals into human milk. Pediatrics. 2001 Sep;108(3):776-89. Abstract Full text (link to original source) Full text (in our servers)
  8. Valdivieso A, Valdés G, Spiro TE, Westerman RL. Minoxidil in breast milk. Ann Intern Med. 1985 Abstract

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