Last update: Jan. 10, 2015

Methyldopa

Very Low Risk for breastfeeding


Safe. Compatible.
Minimal risk for breastfeeding and infant.

Excreted into breast milk in non-significant amount without side-effects observed in breastfed infants from mothers who were on this medication. Plasma levels in those infants were undetectable or very low.

Prolactin level may be increased with the appearance of galactorrhea. Such increase of Prolactin level will not affect breastfeeding ability of a mother who has an established lactation.

The American Academy of Pediatrics rates is as compatible with breastfeeding.

List of Medicines (WHO-2002): compatible with Breastfeeding.

Alternatives

We do not have alternatives for Methyldopa since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.
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Other names

Methyldopa is also known as


Group

Methyldopa belongs to this group or family:

Tradenames

Main tradenames from several countries containing Methyldopa in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 60 %
Molecular weight 211 daltons
Protein Binding 12 %
Tmax 6 hours
T1/2 1,5 hours
M/P ratio 0,3 -
Theoretical Dose 0,17 mg/Kg/d
Relative Dose 2,1 %
Relat.Ped.Dose 1,6 %

References

  1. Anderson PO. Treating Hypertension During Breastfeeding. Breastfeed Med. 2018 Abstract
  2. Malachias MV, Figueiredo CE, Sass N, Antonello IC, Torloni MR, Bortolotto MRF L. 7th Brazilian Guideline of Arterial Hypertension: Chapter 9 - Arterial Hypertension in pregnancy Arq Bras Cardiol. 2016 Abstract Full text (link to original source) Full text (in our servers)
  3. Serrano Aguayo P, García de Quirós Muñoz JM, Bretón Lesmes I, Cózar León MV. Tratamiento de enfermedades endocrinológicas durante la lactancia. [Endocrinologic diseases management during breastfeeding.] Med Clin (Barc). 2015 Abstract
  4. Dennis AT. Management of pre-eclampsia: issues for anaesthetists. Anaesthesia. 2012 Sep;67(9):1009-20. Abstract Full text (link to original source) Full text (in our servers)
  5. Ghanem FA, Movahed A. Use of antihypertensive drugs during pregnancy and lactation. Cardiovasc Ther. 2008 Abstract Full text (link to original source) Full text (in our servers)
  6. WHO / UNICEF. BREASTFEEDING AND MATERNAL MEDICATION Recommendations for Drugs in the Eleventh WHO Model List of Essential Drugs. Department of Child and Adolescent Health and Development (WHO/UNICEF) 2002 Full text (link to original source) Full text (in our servers)
  7. Beardmore KS, Morris JM, Gallery ED. Excretion of antihypertensive medication into human breast milk: a systematic review. Hypertens Pregnancy. 2002 Abstract Full text (link to original source)
  8. AAP - American Academy of Pediatrics Committee on Drugs. Transfer of drugs and other chemicals into human milk. Pediatrics. 2001 Sep;108(3):776-89. Abstract Full text (link to original source) Full text (in our servers)
  9. White WB, Andreoli JW, Cohn RD. Alpha-methyldopa disposition in mothers with hypertension and in their breast-fed infants. Clin Pharmacol Ther. 1985 Abstract
  10. Hauser GJ, Almog S, Tirosh M, Spirer Z. Effect of alpha-methyldopa excreted in human milk on the breast-fed infant. Helv Paediatr Acta. 1985 Abstract
  11. Jones HM, Cummings AJ. A study of the transfer of alpha-methyldopa to the human foetus and newborn infant. Br J Clin Pharmacol. 1978 Abstract Full text (link to original source) Full text (in our servers)

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