Last update Aug. 30, 2021

Tuberculin

Very Low Risk

Safe. Compatible. Minimal risk for breastfeeding and infant.

Fraction of purified protein isolated from a filtered culture medium of a human strain of Mycobacterium tuberculosis.
Indicated as a test for the diagnosis of tuberculosis.
Intradermal administration.

Plasma absorption from the dermis is nil, so it is very unlikely that a significant amount will pass into breast milk.

Due to its protein nature, it is inactivated in the gastrointestinal tract, not being absorbed (practically nil oral bioavailability), which hinders or prevents the passage into plasma of the infant from ingested breast milk.

It is a test for authorized use in newborns and infants.

The data available on a possible sensitization of infants to tuberculin through breast milk is contradictory and insufficient (Keller 1987, Masters 1982).

Expert authors consider the use of this medication safe during breastfeeding (Hale, LactMed, Lawrence 2016 p424, Schaeffer 2015 p818, Loto 2012).
WHO Essential Medicines List: compatible with breastfeeding (WHO 2002)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Tuberculin is also known as


Tuberculin in other languages or writings:

Group

Tuberculin belongs to this group or family:

Tradenames

Main tradenames from several countries containing Tuberculin in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 0 %

References

  1. Hale TW. Medications & Mothers' Milk. 1991- . Springer Publishing Company. Available from https://www.halesmeds.com Consulted on March 17, 2022 Full text (link to original source)
  2. LactMed. Drugs and Lactation Database (LactMed). Internet. Bethesda (MD): National Library of Medicine (US); 2006-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK501922/ 2006 - Consulted on March 15, 2022 Full text (link to original source)
  3. Lawrence RA, Lawrence RM. Breastfeeding. A guide for the medical profession. Eighth Edition. Philadelphia: Elsevier; 2016
  4. Schaefer C, Peters P, Miller RK. Drugs During Pregnancy and Lactation. Treatment options and risk assessment. Elsevier, Third Edition. 2015
  5. Loto OM, Awowole I. Tuberculosis in pregnancy: a review. J Pregnancy. 2012;2012:379271. Abstract
  6. WHO / UNICEF. BREASTFEEDING AND MATERNAL MEDICATION Recommendations for Drugs in the Eleventh WHO Model List of Essential Drugs. Department of Child and Adolescent Health and Development (WHO/UNICEF) 2002 Full text (link to original source) Full text (in our servers)
  7. Keller MA, Rodgriguez AL, Alvarez S, Wheeler NC, Reisinger D. Transfer of tuberculin immunity from mother to infant. Pediatr Res. 1987 Sep;22(3):277-81. Abstract
  8. Masters PL. Maternal transmission of skin sensitivity to tuberculin. Lancet. 1982 Jul 31;2(8292):276-7. No abstract available. Abstract

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