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Fraction of purified protein isolated from a filtered culture medium of a human strain of Mycobacterium tuberculosis.
Indicated as a test for the diagnosis of tuberculosis.
Intradermal administration.
Plasma absorption from the dermis is nil, so it is very unlikely that a significant amount will pass into breast milk.
Due to its protein nature, it is inactivated in the gastrointestinal tract, not being absorbed (practically nil oral bioavailability), which hinders or prevents the passage into plasma of the infant from ingested breast milk.
It is a test for authorized use in newborns and infants.
The data available on a possible sensitization of infants to tuberculin through breast milk is contradictory and insufficient (Keller 1987, Masters 1982).
Expert authors consider the use of this medication safe during breastfeeding (Hale, LactMed, Lawrence 2016 p424, Schaeffer 2015 p818, Loto 2012).
WHO Essential Medicines List: compatible with breastfeeding (WHO 2002)