Last update May 22, 2025

Цефтазидим

Compatible

Safe product and/or breastfeeding is the best option.

Third generation cephalosporin antibiotic. Injectable, parenteral administration.

Like most cephalosporins, it is excreted in breast milk in very small, clinically insignificant amounts. (Blanco 1983)

Cephalosporins are widely used in paediatrics with very good tolerance, even from the neonatal period, so it is very unlikely that, in small quantities through milk, they can cause problems to the infant.

The possibility of gastroenteritis due to alteration of the intestinal flora must be taken into account. (Ito 1993)

Several medical societies and expert authors consider it safe to use this medication during breastfeeding. (Hale, LactMed, Briggs 2015, Rowe 2013, Fulton 1992)

American Academy of Pediatrics: Maternal Medication Usually Compatible With Breastfeeding (AAP 2001). Eleventh WHO Model List of Essential Drugs 2002: Compatible with breastfeeding. (WHO 2002)

Alternatives

We do not have alternatives for Цефтазидим since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Other names

Цефтазидим is Ceftazidime in Cyrillic.

Is written in other languages:

Group

Цефтазидим belongs to this group or family:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. < 10 %
Molecular weight 637 daltons
Protein Binding 10 (5 - 24) %
VD 0.21 - 0.29 l/Kg
pKa 4.02 -
Tmax 1 - 1.5 hours
T½ 1.5 - 2.8 hours
Theoretical Dose 0.58 - 0.74 mg/Kg/d
Relative Dose 0.6 - 0.7 %
Ped.Relat.Dose 0.8 %

References

  1. van Wattum JJ, Leferink TM, Wilffert B, Ter Horst PGJ. Antibiotics and lactation: An overview of relative infant doses and a systematic assessment of clinical studies. Basic Clin Pharmacol Toxicol. 2019 Jan;124(1):5-17. Abstract
  2. Rowe H, Baker T, Hale TW. Maternal medication, drug use, and breastfeeding. Pediatr Clin North Am. 2013 Feb;60(1):275-94. Abstract
  3. AEMPS. Ceftazidima. Ficha técnica. 2012 Full text (in our servers)
  4. WHO / UNICEF. BREASTFEEDING AND MATERNAL MEDICATION Recommendations for Drugs in the Eleventh WHO Model List of Essential Drugs. Department of Child and Adolescent Health and Development (WHO/UNICEF) 2002 Abstract Full text (link to original source) Full text (in our servers)
  5. AAP - American Academy of Pediatrics Committee on Drugs. Transfer of drugs and other chemicals into human milk. Pediatrics. 2001 Sep;108(3):776-89. Abstract Full text (link to original source) Full text (in our servers)
  6. Ito S, Blajchman A, Stephenson M, Eliopoulos C, Koren G. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993 May;168(5):1393-9. Abstract
  7. Fulton B, Moore LL. Antiinfectives in breastmilk. Part I: Penicillins and cephalosporins. J Hum Lact. 1992 Abstract
  8. Blanco JD, Jorgensen JH, Castaneda YS, Crawford SA. Ceftazidime levels in human breast milk. Antimicrob Agents Chemother. 1983 Abstract Full text (link to original source) Full text (in our servers)

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e-lactancia is a resource recommended by Academy of Breastfeeding Medicine - 2012 of United States of America

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