Last update Jan. 2, 2023

Tripelennamine Citrate

Likely Compatibility

Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.

It is a first generation antihistamine, derived from ethylenediamine, with moderate antimuscarinic and sedative properties. It is used orally to treat hypersensitivity reactions, coughs, and the common cold, and topically to relieve skin itching from insect bites, contact with jellyfish or nettles, or minor skin irritations.

At the date of the last update we did not find any published data on its excretion in breast milk.

The paucity of known pharmacokinetic data does not allow prediction of the amount of its possible excretion in breast milk.

Until more published data is known about this drug in relation to breastfeeding, known safer alternatives are preferable, especially during the neonatal period and in the event of prematurity.

The small dose and poor plasma absorption of most topical dermatological preparations make it unlikely that a significant amount will pass into breast milk. Topical use would be compatible with breastfeeding (AEMPS 2017) as long as it is not applied to the chest or cleaned well before breastfeeding.


Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Tripelennamine Citrate is also known as Tripelennamine Hydrochloride.

Tripelennamine Citrate in other languages or writings:


Main tradenames from several countries containing Tripelennamine Citrate in its composition:


Variable Value Unit
Oral Bioavail. 100 %
Molecular weight 292 daltons
Tmax 2 - 3 hours
2.9 - 4.4 hours


  1. AEMPS. Tripelenamina. Ficha técnica. 2017 Full text (in our servers)
  2. Yeh SY, Todd GD, Johnson RE, Gorodetzky CW, Lange WR. The pharmacokinetics of pentazocine and tripelennamine. Clin Pharmacol Ther. 1986 Jun;39(6):669-76. Abstract

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