Last update Sept. 14, 2022

Trimetazidine Hydrochloride

Limited compatibility

Unsafe. Moderate/severe adverse effects. Compatible under certain circumstances. Follow-up recommended. Use safer alternative or discontinue breastfeeding from 5 to 7 T ½ . Read Commentary.

Trimetazidine or trimetazine is a piperazine derivative indicated for the symptomatic treatment of stable angina pectoris and vertigo, tinnitus and Ménière's disease. Oral administration in three daily doses.

Since the last update we have not found published data on its excretion in breastmilk.


Its effectiveness is questionable and it has worrisome neurological side effects. European Medicines Agency (EMA) has recommended restricting its use and using it only as a second-line adjunctive therapy. (EMA 2012)

Until more published data is known about this drug in relation to breastfeeding, known safer alternatives are preferable, especially during the neonatal period and in the event of prematurity.

Alternatives

  • Amlodipine (Safe substance and/or breastfeeding is the best option.)
  • Diltiazem Hydrochloride (Safe substance and/or breastfeeding is the best option.)
  • Glyceryl Trinitrate (Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.)
  • Hydralazine Hydrochloride (Safe substance and/or breastfeeding is the best option.)
  • Isosorbide Dinitrate (Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.)
  • Metoprolol (Safe substance and/or breastfeeding is the best option.)
  • Nifedipine (Safe substance and/or breastfeeding is the best option.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Trimetazidine Hydrochloride is also known as


Trimetazidine Hydrochloride in other languages or writings:

Group

Trimetazidine Hydrochloride belongs to this group or family:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 85 %
Molecular weight 339 daltons
Protein Binding 16 %
VD 4.8 l/Kg
Tmax 2 - 6 hours
7.8 hours

References

  1. EMA. Trimetazidina. Ficha técnica. 2021 Full text (in our servers)
  2. Servier. Trimetazidine. Drug Summary. 2021 Full text (in our servers)
  3. EMA. European Medicines Agency recommends restricting use of trimetazidine-containing medicines. Press release. 2012 Full text (link to original source) Full text (in our servers)

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