Last update Aug. 27, 2014

Isosorbide Dinitrate

Low Risk

Possibly safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.

The amount of nitrates in breast milk is not related to level of contamination in drinking water (ingest <100 mg/day of nitrate do not produce milk with elevated nitrate levels). By this reason, breastfed babies from regions with nitrate contaminated water do not have increased risk of Metahemoglobinemia like bottle-fed babies do.

The amount of nitrate compounds contained in vasodilator medication is so small that no problems have been reported while breastfeeding.

Alternatives

We do not have alternatives for Isosorbide Dinitrate.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Groups

Isosorbide Dinitrate belongs to these groups or families:

Tradenames

Main tradenames from several countries containing Isosorbide Dinitrate in its composition:

List of 9 tradenames

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 25 %
Molecular weight 236 daltons
Protein Binding 30 %
T½ 1 hours

References

  1. Kearney L, Wright P, Fhadil S, Thomas M. Postpartum Cardiomyopathy and Considerations for Breastfeeding. Card Fail Rev. 2018 Abstract Full text (link to original source) Full text (in our servers)
  2. WHO / UNICEF. BREASTFEEDING AND MATERNAL MEDICATION Recommendations for Drugs in the Eleventh WHO Model List of Essential Drugs. Department of Child and Adolescent Health and Development (WHO/UNICEF) 2002 Abstract Full text (link to original source) Full text (in our servers)
  3. Kirsten R, Nelson K, Kirsten D, Heintz B. Clinical pharmacokinetics of vasodilators. Part II. Clin Pharmacokinet. 1998 Abstract

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