Last update Feb. 2, 2024
Likely Compatibility
Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.
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Isosorbide Mononitrate in other languages or writings:
Isosorbide Mononitrate belongs to this group or family:
Main tradenames from several countries containing Isosorbide Mononitrate in its composition:
Variable | Value | Unit |
---|---|---|
Oral Bioavail. | 93 | % |
Molecular weight | 191 | daltons |
Protein Binding | 5 | % |
VD | 0.7 | l/Kg |
pKa | 13.34 | - |
Tmax | 0.5 - 1 | hours |
T½ | 4 - 5 | hours |
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e-lactancia is a resource recommended by La Liga de la Leche, España of Spain
Would you like to recommend the use of e-lactancia? Write to us at corporate mail of APILAM
Isosorbide mononitrate is an active metabolite of the vasodilator isosorbide dinitrate. It is used in the treatment of angina pectoris, heart failure and pulmonary hypertension. Oral administration.
At the time of the last update, we found no published data on its excretion in breast milk.
If used during breastfeeding, it is advisable to monitor the infant for symptoms of drowsiness, lethargy or poor feeding and to monitor for weight gain. (Kearney 2018)
The amount of nitrate/nitrite in breast milk is not related to the level of nitrate ingested by the mother in water, food or medications (Paszkowski 1989). Ingestion of up to 100 mg/day of nitrate does not increase nitrate levels in breast milk. (Dusdieker 1996). For this reason, breastfed infants from regions with nitrate-contaminated water do not have an increased risk of methemoglobinemia, in contrast to bottle-fed infants.
The amount of nitrate compounds contained in vasodilator drugs is so small that no nitrate toxicity problems, such as methemoglobinemia, have been reported in breastfed infants whose mothers used them.