Last update Feb. 23, 2025
Likely Compatibility
Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.
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Tigecycline in other languages or writings:
Main tradenames from several countries containing Tigecycline in its composition:
Variable | Value | Unit |
---|---|---|
Oral Bioavail. | Baja / Poor | % |
Molecular weight | 586 | daltons |
Protein Binding | 71 - 89 | % |
VD | 7 - 9 | l/Kg |
pKa | 3.17 | - |
T½ | 27 - 43 | hours |
Write us at elactancia.org@gmail.com
e-lactancia is a resource recommended by Amamanta of Spain
Would you like to recommend the use of e-lactancia? Write to us at corporate mail of APILAM
Tigecycline is a tetracycline-like glycylcycline antibiotic used in the treatment of severe intra-abdominal, skin and soft tissue infections caused by multiresistant germs. Intravenous administration.
On latest update no relevant data related to breastfeeding were found.
Its pharmacokinetic data (large volume of distribution, moderately high molecular weight and relatively high percentage of protein binding) make it unlikely to pass into milk in significant quantities.
Even more, low oral bioavailability makes absorption from ingested breast milk into infant’s blood be nil or scanty. However, in premature infants and neonates in early postpartum, blood levels are likely higher due to increased gut absorption.
Nonetheless, a safer alternative with other known antibiotic is preferred until more information is available.