Last update Feb. 23, 2025

Tigecycline

Likely Compatibility

Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.

Tigecycline is a tetracycline-like glycylcycline antibiotic used in the treatment of severe intra-abdominal, skin and soft tissue infections caused by multiresistant germs. Intravenous administration.

On latest update no relevant data related to breastfeeding were found.

Its pharmacokinetic data (large volume of distribution, moderately high molecular weight and relatively high percentage of protein binding) make it unlikely to pass into milk in significant quantities.

Even more, low oral bioavailability makes absorption from ingested breast milk into infant’s blood be nil or scanty. However, in premature infants and neonates in early postpartum, blood levels are likely higher due to increased gut absorption.

Nonetheless, a safer alternative with other known antibiotic is preferred until more information is available.

Alternatives

  • Aztreonam (Safe product and/or breastfeeding is the best option.)
  • Imipenem + Cilastatin (Safe product and/or breastfeeding is the best option.)
  • Vancomycin (Safe product and/or breastfeeding is the best option.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Other names

Tigecycline in other languages or writings:

Group

Tigecycline belongs to this group or family:

Tradenames

Main tradenames from several countries containing Tigecycline in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. Baja / Poor %
Molecular weight 586 daltons
Protein Binding 71 - 89 %
VD 7 - 9 l/Kg
pKa 3.17 -
T½ 27 - 43 hours

References

  1. PDR Tygacil _ Drug Summary PDR 2014 Full text (link to original source) Full text (in our servers)
  2. Mitrano JA, Spooner LM, Belliveau P. Excretion of antimicrobials used to treat methicillin-resistant Staphylococcus aureus infections during lactation: safety in breastfeeding infants. Pharmacotherapy. 2009 Sep;29(9):1103-9. Abstract
  3. HGUA Tigeciclina Ficha técnica 2007 Full text (in our servers)
  4. CUN Tigeciclina Fiche técnica 2007 Full text (link to original source) Full text (in our servers)
  5. Agwuh KN, MacGowan A. Pharmacokinetics and pharmacodynamics of the tetracyclines including glycylcyclines. J Antimicrob Chemother. 2006 Abstract
  6. Meagher AK, Ambrose PG, Grasela TH, Ellis-Grosse EJ. The pharmacokinetic and pharmacodynamic profile of tigecycline. Clin Infect Dis. 2005 Abstract Full text (link to original source) Full text (in our servers)
  7. Muralidharan G, Micalizzi M, Speth J, Raible D, Troy S. Pharmacokinetics of tigecycline after single and multiple doses in healthy subjects. Antimicrob Agents Chemother. 2005 Abstract Full text (link to original source) Full text (in our servers)

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