Last update Feb. 28, 2023

Aztreonam

Very Low Risk

Safe. Compatible. Minimal risk for breastfeeding and infant.

Monobactamic antibiotic which is similar to penicillins. Indicated for the treatment of infections caused by susceptible Gram-negative aerobic organisms. Intravenous administration.

It is excreted into breast milk in insignificant amount. (Ito 1990, Fleiss 1985)

Its almost zero oral bioavailability makes it difficult for it to pass to the infant plasma from ingested breast milk, except in premature infants and in the immediate neonatal period in which there may be greater intestinal permeability.

It is commonly prescribed to children and newborns. 

Several medical societies and expert authors consider the use of this medication to be safe or very probably safe during breastfeeding. (Hale, Middleton 2020, Briggs 2015, Schaefer 2015)

American Academy of Pediatrics: medication usually compatible with breastfeeding.(AAP 2001)

Alternatives

We do not have alternatives for Aztreonam since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Other names

Aztreonam in other languages or writings:

Group

Aztreonam belongs to this group or family:

Tradenames

Main tradenames from several countries containing Aztreonam in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. < 1 %
Molecular weight 435 daltons
Protein Binding 56 %
VD 0.16 - 0.42 l/Kg
pKa -1.5 -
Tmax 0.6 - 1.3 hours
T½ 1.7 (1.5 - 2) hours
M/P ratio 0.01 -
Theoretical Dose 0.15 mg/Kg/d
Relative Dose 0.18 - 0.45 %
Ped.Relat.Dose 0.125 %

References

  1. Hale TW. Medications & Mothers' Milk. 1991- . Springer Publishing Company. Available from https://www.halesmeds.com Consulted on March 17, 2022 Full text (link to original source)
  2. Middleton PG, Gade EJ, Aguilera C, MacKillop L, Button BM, Coleman C, Johnson B, Albrechtsen C, Edenborough F, Rigau D, Gibson PG, Backer V. ERS/TSANZ Task Force Statement on the management of reproduction and pregnancy in women with airways diseases. Eur Respir J. 2020 Feb 6;55(2). pii: 1901208. Abstract Full text (link to original source) Full text (in our servers)
  3. Briggs GG, Freeman RK, Towers CV, Forinash AB. Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk. Wolters Kluwer Health. Tenth edition (acces on line) 2015
  4. Schaefer C, Peters P, Miller RK. Drugs During Pregnancy and Lactation. Treatment options and risk assessment. Elsevier, Third Edition. 2015
  5. AAP - American Academy of Pediatrics Committee on Drugs. Transfer of drugs and other chemicals into human milk. Pediatrics. 2001 Sep;108(3):776-89. Abstract Full text (link to original source) Full text (in our servers)
  6. Ito K, Hirose R, Tamaya T, Yamada Y, Izumi K. [Pharmacokinetic and clinical studies on aztreonam in the perinatal period]. Jpn J Antibiot. 1990 \ Apr;43(4):719-26. 1990 Abstract
  7. Mattie H. Clinical pharmacokinetics of aztreonam. Clin Pharmacokinet. 1988 Mar;14(3):148-55. 1988 Abstract
  8. Nau H. Clinical pharmacokinetics in pregnancy and perinatology. II. Penicillins. Dev Pharmacol Ther. 1987 Abstract
  9. Fleiss PM, Richwald GA, Gordon J, Stern M, Frantz M, Devlin RG. Aztreonam in human serum and breast milk. Br J Clin Pharmacol. 1985 Abstract Full text (link to original source) Full text (in our servers)

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