Last update Oct. 14, 2022

Ticarcillin Sodium + Clavulanic Acid

Very Low Risk

Safe. Compatible. Minimal risk for breastfeeding and infant.

Ticarcillin is a carboxypenicillin used in the treatment of serious gram-negative infections, especially those due to Pseudomonas aeruginosa. Clavulanic acid is a beta-lactamase inhibitor produced by Staphylococcus aureus that is used to improve the efficacy of beta-lactam antibiotics. Intravenous administration.

Ticarcillin is excreted into breastmilk in a clinically insignificant amount (Matsuda 1984, von Kobyletzki 1983). Data on the excretion of clavulanic acid in breast milk are unknown.

The null oral bioavailability of Ticarcillin minimizes the passage into plasma of the infant from ingested breast milk, except in the premature and in the immediate neonatal period in which there may be greater intestinal permeability.

Although rare, the possibility of transient gastroenteritis due to alteration of the intestinal flora in infants whose mothers take antibiotics should be taken into account. (Ito 1993).

Expert authors consider the use of this medication to be safe during breastfeeding. (LacMed, Briggs 2015)


See below the information of this related product:

Alternatives

We do not have alternatives for Ticarcillin Sodium + Clavulanic Acid since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.
DONATE NOW

Other names

Ticarcillin Sodium + Clavulanic Acid in other languages or writings:

  • C15H14N2Na2O6S2. / C8H9NO5 (Molecular formula)
  • J01CR03 (ATC Code/s)

Group

Ticarcillin Sodium + Clavulanic Acid belongs to this group or family:

Tradenames

Main tradenames from several countries containing Ticarcillin Sodium + Clavulanic Acid in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 0 / %
Molecular weight 428 / 199 daltons
Protein Binding 54 / 25 %
VD -- / 0.17 l/Kg
pKa 3.09 / 3.32 -
Tmax 1 / 1.04 ± 0.80 hours
T½ 1.1 / 0.8 - 1.5 hours
Theoretical Dose 0.3 / mg/Kg/d
Relative Dose 0.4 / %

References

  1. LactMed. Drugs and Lactation Database (LactMed). Internet. Bethesda (MD): National Library of Medicine (US); 2006-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK501922/ 2006 - Consulted on March 15, 2022 Full text (link to original source)
  2. Briggs GG, Freeman RK, Towers CV, Forinash AB. Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk. Wolters Kluwer Health. Tenth edition (acces on line) 2015
  3. Ito S, Blajchman A, Stephenson M, Eliopoulos C, Koren G. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993 May;168(5):1393-9. Abstract
  4. Matsuda S. Transfer of antibiotics into maternal milk. Biol Res Pregnancy Perinatol. 1984;5(2):57-60. Abstract
  5. von Kobyletzki D, Dalhoff A, Lindemeyer H, Primavesi CA. Ticarcillin serum and tissue concentrations in gynecology and obstetrics. Infection. 1983 May-Jun;11(3):144-9. Abstract

Total visits

21,253

Help us improve this entry

How to cite this entry

Do you need more information or did not found what you were looking for?

   Write us at elactancia.org@gmail.com

e-lactancia is a resource recommended by Academy of Breastfeeding Medicine - 2006 of United States of America

Would you like to recommend the use of e-lactancia? Write to us at corporate mail of APILAM