Last update June 4, 2016

Tianeptine Sodium

Low Risk

Moderately safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.

Drug with similar efficacy as other antidepressants with tricyclic and selective inhibitors of serotonin reuptake characteristics.
Risk of abuse and dependence with addiction, which is a reason not to be authorized in many countries.
Neonatal Abstinence Syndrome has been published after abusing doses (more than 100 times higher than usual) of Tianeptine during pregnancy (Bence 2016).

At latest update no published data on excretion into breast milk were found.

Its high plasma protein-binding capacity makes it unlikely the passage of drug into breast milk.

It may, like other antidepressants, increase Prolactin levels in the plasma.

Until more published data regarding breastfeeding is available, the use of a known and safer alternative drug should be preferred, especially during the neonatal period and/or in case of premature infant.

Alternatives

  • Imipramine-Hcl ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Paroxetine ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Sertraline Hydrochloride ( Safe. Compatible. Minimal risk for breastfeeding and infant.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Tianeptine Sodium in other languages or writings:

Group

Tianeptine Sodium belongs to this group or family:

Tradenames

Main tradenames from several countries containing Tianeptine Sodium in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 99 %
Molecular weight 459 daltons
Protein Binding 95 %
VD 0.8 l/Kg
Tmax 1 - 2 hours
2.5 - 3 hours

References

  1. Bence C, Bonord A, Rebillard C, Vaast P, Alexandre C, Jardri R, Rolland B. Neonatal Abstinence Syndrome Following Tianeptine Dependence During Pregnancy. Pediatrics. 2016 Abstract
  2. Centro Andaluz de Documentación e Información de Medicamentos (CADIME). Tianeptina. Ficha evaluación de medicamentos. 2015 Abstract Full text (link to original source) Full text (in our servers)
  3. AEMPS. Tianeptina. Ficha técnica. 2014 Full text (in our servers)
  4. Vadachkoria D, Gabunia L, Gambashidze K, Pkhaladze N, Kuridze N. Addictive potential of Tianeptine - the threatening reality. Georgian Med News. 2009 Abstract
  5. Kisa C, Bulbul DO, Aydemir C, Goka E. Is it possible to be dependent to Tianeptine, an antidepressant? A case report. Prog Neuropsychopharmacol Biol Psychiatry. 2007 Abstract
  6. Filho RB, Domingues L, Naves L, Ferraz E, Alves A, Casulari LA. Polycystic ovary syndrome and hyperprolactinemia are distinct entities. Gynecol Endocrinol. 2007 Abstract
  7. [No authors listed] Tianeptine abuse: yet again. Prescrire Int. 2007 Abstract
  8. Mück-Seler D, Pivac N, Sagud M, Jakovljević M, Mihaljević-Peles A. The effects of paroxetine and tianeptine on peripheral biochemical markers in major depression. Prog Neuropsychopharmacol Biol Psychiatry. 2002 Abstract
  9. Delalleau B, Dulcire C, Le Moine P, Kamoun A. Analysis of the side effects of tianeptine. Clin Neuropharmacol. 1988 Abstract
  10. Royer RJ, Albin H, Barrucand D, Salvadori-Failler C, Kamoun A. Pharmacokinetic and metabolic parameters of tianeptine in healthy volunteers and in populations with risk factors. Clin Neuropharmacol. 1988 Abstract
  11. Dresse A, Rosen JM, Brems H, Masset H, Defrance R, Salvadori C. Influence of food on tianeptine and its main metabolite kinetics. J Clin Pharmacol. 1988 Abstract

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