Last update June 23, 2022

Thioproperazine Mesilate

High Risk

Poorly safe. Evaluate carefully. Use safer alternative or interrupt breastfeeding 3 to 7 T ½ (elimination half-lives). Read the Comment.

Typical, first-generation antipsychotic. It is a phenothiazine with properties similar to those of chlorpromazine. It is used in the treatment of schizophrenia, mania, and other psychoses. Single-dose oral administration.

At the date of the last update, there was no published data available on its excretion in human milk.

Product with very few and old bibliographic references, without known pharmacokinetic data and marketed in few countries.

It can cause galactorrhea. (Mendels 1964)

Known safer alternatives are preferable (Parikh 2014), especially during the neonatal period and in the event of prematurity.

See below the information of this related product:


  • Chlorpromazine (Possibly safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.)
  • Olanzapine ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Perphenazine ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Quetiapine Fumarate ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Trifluoperazine Hydrochloride ( Safe. Compatible. Minimal risk for breastfeeding and infant.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Thioproperazine Mesilate is also known as

Thioproperazine Mesilate in other languages or writings:


Thioproperazine Mesilate belongs to these groups or families:


Main tradenames from several countries containing Thioproperazine Mesilate in its composition:


Variable Value Unit
Molecular weight 639 daltons


  1. Parikh T, Goyal D, Scarff JR, Lippmann S. Antipsychotic drugs and safety concerns for breast-feeding infants. South Med J. 2014 Abstract
  2. MENDELS J. THIOPROPERAZINE-INDUCED LACTATION. Am J Psychiatry. 1964 Aug;121:190-1. No abstract available. Abstract

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