Last update May 2, 2022

スクラルファート

Very Low Risk

Safe. Compatible. Minimal risk for breastfeeding and infant.

It is a glycoside-sulphate derivative (sucrose) plus aluminum.

 It is indicated in peptic ulcer and chronic gastritis. Oral administration two to six times a day.

At latest update no published data on excretion into breastmilk were found.



Pharmacokinetic data (virtually non-absorbed with a high molecular weight) make it very unlikely the excretion into breastmilk in significant amounts, which in addition it would not be absorbed through the infant's intestine.



Medication with authorized use on infants.

Several medical societies and expert authors consider the use of this medication possible during breastfeeding. (Hale, LactMed, Thélin 2022, Briggs 2015, Schaefer 2015, Mahadevan 2006, Richter 2005, Hagemann 1998, Broussard 1998)

A cream with sucralfate, zinc, and copper has been used to treat nipple cracks. (Talaee 2021)

Alternatives

We do not have alternatives for スクラルファート since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Group

スクラルファート belongs to this group or family:

Tradenames

Main tradenames from several countries containing スクラルファート in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. < 5 %
Molecular weight 1.559 daltons
VD - l/Kg
Tmax - hours
- hours
M/P ratio ≈ 0 -
Theoretical Dose ≈ 0 mg/Kg/d
Relative Dose ≈ 0 %

References

  1. Hale TW. Medications & Mothers' Milk. 1991- . Springer Publishing Company. Available from https://www.halesmeds.com Consulted on March 17, 2022 Full text (link to original source)
  2. LactMed. Drugs and Lactation Database (LactMed). Internet. Bethesda (MD): National Library of Medicine (US); 2006-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK501922/ 2006 - Consulted on March 15, 2022 Full text (link to original source)
  3. Talaee R, Mohammadzadeh M, Rahimi H. Comparing the combination of copper, zinc, and sucralfate (Cicalfate®) with white soft paraffin in the treatment of cracked nipples. Iran J Dermatol. 2021;24:18–23. Full text (link to original source) Full text (in our servers)
  4. Thélin CS, Richter JE. Review article: the management of heartburn during pregnancy and lactation. Aliment Pharmacol Ther. 2020 Feb;51(4):421-434. Abstract
  5. Briggs GG, Freeman RK, Towers CV, Forinash AB. Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk. Wolters Kluwer Health. Tenth edition (acces on line) 2015
  6. Schaefer C, Peters P, Miller RK. Drugs During Pregnancy and Lactation. Treatment options and risk assessment. Elsevier, Third Edition. 2015
  7. Mahadevan U, Kane S. American gastroenterological association institute technical review on the use of gastrointestinal medications in pregnancy. Gastroenterology. 2006 Jul;131(1):283-311. Review. Abstract Full text (link to original source) Full text (in our servers)
  8. Richter JE. Review article: the management of heartburn in pregnancy. Aliment Pharmacol Ther. 2005 Nov 1;22(9):749-57. Review. Abstract Full text (in our servers)
  9. Broussard CN, Richter JE. Treating gastro-oesophageal reflux disease during pregnancy and lactation: what are the safest therapy options? Drug Saf. 1998 Oct;19(4):325-37. Review. Abstract
  10. Hagemann TM. Gastrointestinal medications and breastfeeding. J Hum Lact. 1998 Sep;14(3):259-62. Review. Abstract

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