Last update May 20, 2025

Sodium Picosulfate

Compatible

Safe product and/or breastfeeding is the best option.

Laxative stimulant by irritation of intestinal mucosa similar to bisacodyl. Oral administration.

Its low oral bioavailability due to minimal intestinal absorption results in very low plasma levels, which explains the null passage into breast milk observed: undetectable levels. (Friedrich 2011).

Authorized use in infants from one month of age

Expert authors consider safe to use this medication during breastfeeding. (LactMed, Gharehbaghi 2016)

To avoid or treat constipation, a balanced diet, rich in fiber, plenty of fluids and sport are essential.

Alternatives

  • Docusate (Safe product and/or breastfeeding is the best option.)
  • Lactulose (Safe product and/or breastfeeding is the best option.)
  • Liquid Paraffin (Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

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Other names

Sodium Picosulfate in other languages or writings:

Group

Sodium Picosulfate belongs to this group or family:

Tradenames

Main tradenames from several countries containing Sodium Picosulfate in its composition:

List of 52 tradenames

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 5 %
Molecular weight 499 daltons
T½ 7 hours

References

  1. LactMed. Drugs and Lactation Database (LactMed). Internet. Bethesda (MD): National Library of Medicine (US); 2006-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK501922/ 2006 - Consulted on April 16, 2024 Full text (link to original source)
  2. Gharehbaghi K, Gharehbaghi DR, Wierrani F, Sliutz G. [Treatment of Chronic Functional Constipation during Pregnancy and Lactation]. Z Geburtshilfe Neonatol. 2016 Abstract
  3. Müller-Lissner S. Pharmacokinetic and pharmacodynamic considerations for the current chronic constipation treatments. Expert Opin Drug Metab Toxicol. 2013 Abstract
  4. Friedrich C, Richter E, Trommeshauser D, de Kruif S, van Iersel T, Mandel K, Gessner U. Absence of excretion of the active moiety of bisacodyl and sodium picosulfate into human breast milk: an open-label, parallel-group, multiple-dose study in healthy lactating women. Drug Metab Pharmacokinet. 2011 Abstract Full text (link to original source) Full text (in our servers)

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e-lactancia is a resource recommended by Academy of Breastfeeding Medicine - 2012 of United States of America

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