Last update July 10, 2023
Likely Compatibility
Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.
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Sodium Gamma-hydroxybutyrate, γ-hydroxybutyric acid, Gamma-hydroxybutyric acid (GHB) is also known as Sodium Oxybate. Here it is a list of alternative known names::
Sodium Gamma-hydroxybutyrate, γ-hydroxybutyric acid, Gamma-hydroxybutyric acid (GHB) in other languages or writings:
Sodium Gamma-hydroxybutyrate, γ-hydroxybutyric acid, Gamma-hydroxybutyric acid (GHB) belongs to these groups or families:
Variable | Value | Unit |
---|---|---|
Oral Bioavail. | 88 | % |
Molecular weight | 126 | daltons |
Protein Binding | < 1 | % |
VD | 0.2 - 0.4 | l/Kg |
pKa | 4.44 | - |
Tmax | 0.5 - 2 | hours |
T½ | 0.5 - 1 | hours |
M/P ratio | 0.2 - 0.6 | - |
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e-lactancia is a resource recommended by Academy of Breastfeeding Medicine - 2015 of United States of America
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Gamma-Hydroxybutyric acid (GHB) is a natural substance in the body normally found in the central nervous system and also in milk with levels of 0.1 - 1.03 mg/L. (Busardò 2016).Its sodium salt, sodium oxybate, and other salts (calcium, potassium) are used in the treatment of narcolepsy and alcohol withdrawal syndrome. Oral administration in two nightly doses 4 hours apart.
Used as a drug of abuse because of its central nervous system depressant effects. (Felmlee 2021, Busardò 2015). Gamma butyro lactone (GBL) and 1,4-butanediol are precursors of Gamma-HydroxyButyric acid (GHB) and have the same effects as GHB.
Limited data indicate that it is excreted in breast milk in clinically insignificant amount (Barker 2017, Busardò 2017 and 2016 ) and no problems have been observed in two infants whose mothers were taking it (Barker 2017, Busardò 2016, Gashlin 2016). Two mothers breastfed just before each dose and then waited 4 hours to breastfeed again. (Barker 2017, Gashlin 2016)
Given its rapid half-life, at 4 - 5 hours oxybate milk levels are back in the normal range. (Barker 2017, Busardò 2016)
Intestinal absorption of the drug and plasma levels decrease significantly (up to 58%) with simultaneous administration of a meal, especially if it is fatty in content (Jazz Ph 2022), which would protect the infant.
Oxybate may increase prolactin levels. (Donjacour 2011, Van Cauter 1997)
The use of this drug in high doses as a drug of abuse has risks of very serious side effects (Busardò 2015) and is not compatible with breastfeeding.
Monitor drowsiness and adequate infant feeding.
Bed-sharing with the infant (co-sleeping) is not recommended if taking this drug.
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