Last update Oct. 12, 2022
It is a reuptake inhibitor of serotonin, norepinephrine and, to a lesser extent, dopamine, structurally related to amphetamine. It has been used in the treatment of obesity. Oral administration once daily.
On latest update relevant published data on breastfeeding were not found.
Because of high protein-binding, excretion into breast milk seems unlikely.
The more T1/2 elapsed, the less plasma concentration (and in breast milk) of the drug. Its metabolite M2 has a T1/2 of 17 hours (Abbott 2000), which would make it necessary to stop breastfeeding for 51 to 119 hours after administration.
May or may not cause increased prolactin and galactorrhea. (Soares 2011, Florakis 2008)
Because of cardiovascular side effects (Arrhythmia, Hypertension, Heart infarction) several regulatory agencies have withdrawn it from the market in many countries. (EMEA 2010, FDA 2010, MHRA 2010)
There is good quality evidence that exclusive breastfeeding helps to regain pre-pregnancy weight earlier than if breastfeeding is partial (mixed) or there is no breastfeeding, and that prolonged breastfeeding helps maintain that loss and as well as body fat loss.(Jayasinghe 2021, Schalla 2017, López 2016, Jarlenski 2014, Sámano 2013, Neville 2014, Hatsu 2008, Dewey 2004, 2001 y 1993, Kramer 1993)
Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.
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e-lactancia is a resource recommended by Academy of Breastfeeding Medicine - 2012 of United States of America
Would you like to recommend the use of e-lactancia? Write to us at corporate mail of APILAM