Last update May 16, 2023

Rocuronium Bromide

Compatible

Safe substance and/or breastfeeding is the best option.

It is an analog of vecuronium, non-depolarizing muscle relaxant drug with a peripheral action, that is used as premedication for endotracheal intubation, general anesthesia and mechanical ventilation. Intravenous administration.

Since the last update we have not found published data on its excretion in breastmilk.

Its moderately elevated molecular weight and rapid half-life elimination period (about 15 minutes) make it highly unlikely that significant quantities will pass into breast milk. (Dalal 2014)

Also, its low oral bioavailability renders the pass of this agent to the infant's plasma highly unlikely.

Breastfed infants have not shown any problem after 1.5 to 5 hours of anesthesia time period with Rocuronio (additional drugs like Propofol, Remifentanil and Xenon were used). (Stuttmann 2010)

Rocuronium does not prevent a mother from breast feeding her baby shortly after recovering from anesthesia if she is awake and in good condition.

Experts authors consider the use of this medication to be probably compatible during breastfeeding. (Briggs 2015, Howie 2006)

Alternatives

We do not have alternatives for Rocuronium Bromide since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Other names

Rocuronium Bromide is also known as Rocuronium. Here it is a list of alternative known names::


Group

Rocuronium Bromide belongs to this group or family:

Tradenames

Main tradenames from several countries containing Rocuronium Bromide in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. ≈ 0 %
Molecular weight 610 daltons
Protein Binding 30 %
VD 0.2 - 0.3 l/Kg
T½ 0.23 ± 0.04 hours

References

  1. Briggs GG, Freeman RK, Towers CV, Forinash AB. Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk. Wolters Kluwer Health. Tenth edition (acces on line) 2015
  2. Dalal PG, Bosak J, Berlin C. Safety of the breast-feeding infant after maternal anesthesia. Paediatr Anaesth. 2014 Abstract
  3. Stuttmann R, Schäfer C, Hilbert P, Meyer MR, Maurer HH. The breast feeding mother and xenon anaesthesia: four case reports. Breast feeding and xenon anaesthesia. BMC Anesthesiol. 2010 Abstract Full text (link to original source) Full text (in our servers)
  4. Howie WO, McMullen PC. Breastfeeding problems following anesthetic administration. J Perinat Educ. 2006 Abstract Full text (link to original source) Full text (in our servers)
  5. Ferriols Lisart R,Ferriols Lisart F. Farmacología clínica y usos terapéuticos del Mivacurio. Farm Hosp. 1997 Full text (in our servers)

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