Last update March 25, 2022

Rimopride Citrate

Likely Compatibility

Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.

Mosapride, a substituted benzamide, is a prokinetic drug that increases gastrointestinal motility and accelerates gastric emptying. Used in gastritis and gastroesophageal reflux. Oral administration.

At the date of the last update we did not find any published data on its excretion in breast milk.

Its pharmacokinetic data (very high percentage of protein binding and moderately high molecular weight) make it highly unlikely that significant quantities will pass into breast milk.

No cardiac arrhythmias have been reported in patients treated with mosaprida, unlike what happens with a similar drug, cisapride. (Tack 2012, Cho 2004, Endo 2002)

Until more published data is known about this drug in relation to breastfeeding, known safer alternatives are preferable, especially during the neonatal period and in the event of prematurity.


See below the information of this related product:

  • Cisapride (Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.)

Alternatives

  • Domperidone (Safe substance and/or breastfeeding is the best option.)
  • Metoclopramide (Safe substance and/or breastfeeding is the best option.)
  • Omeprazole (Safe substance and/or breastfeeding is the best option.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Other names

Rimopride Citrate is also known as Mosapride Citrate.


Rimopride Citrate in other languages or writings:

Group

Rimopride Citrate belongs to this group or family:

Tradenames

Main tradenames from several countries containing Rimopride Citrate in its composition:

Pharmacokinetics

Variable Value Unit
Molecular weight 650 daltons
Protein Binding 99 %
pKa 14.46 -
Tmax 0.8 ± 0.1 hours
T½ 2.4 hours

References

  1. Camarillo Cárdenas KP, García González J, Argüelles Tello FA, Ocampo Ramírez JA, Moreno Hernández JB, Pendela MM. Relative bioavailability and pharmacokinetic comparison of a fixed-dose combination tablet of mosapride, pancreatin, and simethicone relative to single-component mosapride tablets in healthy Mexican subjects. Fundam Clin Pharmacol. 2022 Apr;36(2):427-435. Consulted on March 25, 2022 Abstract
  2. MIMS. Mosapride (Gasmotin). Internet. 2022 Consulted on March 25, 2022 Full text (link to original source)
  3. Tack J, Camilleri M, Chang L, Chey WD, Galligan JJ, Lacy BE, Müller-Lissner S, Quigley EM, Schuurkes J, De Maeyer JH, Stanghellini V. Systematic review: cardiovascular safety profile of 5-HT(4) agonists developed for gastrointestinal disorders. Aliment Pharmacol Ther. 2012 Apr;35(7):745-67. Abstract
  4. Kim SH, Park YS, Kim JM, Park HJ, Lee MH, Park HK, Kim YJ, Cho SH, Shaw LM, Kang JS. Pharmacokinetic and bioavailability studies of 5 mg mosapride tablets in healthy Korean volunteers. Int J Clin Pharmacol Ther. 2012 Jul;50(7):524-31. Abstract
  5. Huang J, Tian Y, Zhang ZJ, Li J, Cao X. Pharmacokinetics and bioequivalence study of two mosapride citrate formulations after single-dose administration in healthy Chinese male volunteers. Arzneimittelforschung. 2011;61(3):167-72. Abstract
  6. Cho YK, Choi MG, Kim SH, Lee IS, Kim SW, Chung IS, Lee SY, Choi SC, Seol SY. [The effect of mosapride on quality of life in functional dyspepsia]. Korean J Gastroenterol. 2004 Mar;43(3):160-7. Korean. Abstract
  7. Endo J, Nomura M, Morishita S, Uemura N, Inoue S, Kishi S, Kawaguchi R, Iga A, Ito S, Nakaya Y. Influence of mosapride citrate on gastric motility and autonomic nervous function: evaluation by spectral analyses of heart rate and blood pressure variabilities, and by electrogastrography. J Gastroenterol. 2002;37(11):888-95. Abstract
  8. Sakashita M, Yamaguchi T, Miyazaki H, Sekine Y, Nomiyama T, Tanaka S, Miwa T, Harasawa S. Pharmacokinetics of the gastrokinetic agent mosapride citrate after single and multiple oral administrations in healthy subjects. Arzneimittelforschung. 1993 Aug;43(8):867-72. Abstract

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