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Rabeprazole is a proton pump inhibitor (PPI) with actions and uses similar to those of omeprazole. It is indicated in the treatment of peptic ulcer and gastroesophageal reflux. Oral administration once daily.
At latest update, relevant information on excretion into breast milk was not found.
Its pharmacokinetic data (very high percentage of protein binding and short half-life) make it highly unlikely that significant quantities will pass into breast milk.
Both Omeprazole and Pantoprazole, from the same pharmacological group (PPI) and with similar pharmacokinetic characteristics, are excreted in insignificant amounts in breast milk.
Since it's neutralized by the acid pH of stomach, capsules with enteric coated granules are used. Because of this, it is thought that the small quantity of Lansoprazole that may reach the breast milk would be neutralized by infant's stomach. In addition, absorption is greatly decreased by the presence of food.
No changes in prolactinemia have been seen with the use of rabeprazole. (Damman 1999)
Until more published data is known about this drug in relation to breastfeeding, known safer alternatives are preferable, especially during the neonatal period and in the event of prematurity.