Last update June 23, 2022

Propericyazine

Likely Compatibility

Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.

Typical, first-generation antipsychotic. Periciazine, metabolite of propericiazine,  is a phenothiazine derivative with general properties similar to those of chlorpromazine. It is used in the treatment of schizophrenia, bipolar disorder, disturbed behaviour and severe anxiety. Oral administration two times a day.

It is excreted in breast milk in a clinically insignificant amount. (Saito 2022)

There are very few bibiographical references of this product.

Until more published data is known about this drug in relation to breastfeeding, known safer alternatives are preferable (Parikh 2014), especially during the neonatal period and in the event of prematurity.


See below the information of this related product:

Alternatives

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Propericyazine is also known as Periciazine; Pericyazine.


Propericyazine in other languages or writings:

Groups

Propericyazine belongs to these groups or families:

Tradenames

Main tradenames from several countries containing Propericyazine in its composition:

Pharmacokinetics

Variable Value Unit
Molecular weight 366 daltons
pKa 15.18 -
Theoretical Dose 0.000045 mg/Kg/d
Relative Dose 0.027 %

References

  1. Saito J, Tachibana Y, Wada YS, Yakuwa N, Kawasaki H, Suzuki T, Sago H, Yamatani A, Murashima A. Transfer of brotizolam, periciazine, and sulpiride in cord blood and breast milk, and alprazolam in breast milk: a case report. J Pharm Health Care Sci. 2022 Apr 1;8(1):10. Consulted on May 24, 2022 Abstract Full text (link to original source)
  2. Parikh T, Goyal D, Scarff JR, Lippmann S. Antipsychotic drugs and safety concerns for breast-feeding infants. South Med J. 2014 Abstract

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