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Nonsteroidal anti-inflammatory drug (NSAID) derived from indomethacin-related indoleacetic acid. It is a pro-drug of indomethacin conjugated with proglumide, a gastric protector that inhibits gastric secretion by being an antagonist of cholecystokinin. It has been used in musculoskeletal and joint disorders. Oral, rectal and topical cream administration at 5%.
At the date of the last update, the authors did not find any published data on its excretion in breast milk.
Although it has a high molecular weight that would hinder its excretion in breast milk, the absence of published pharmacokinetic data does not allow its excretion in breast milk to be predicted.
Product with very few and/or very old bibliographic references, marketed in few countries.
Safer known alternatives are preferable during breastfeeding, especially during the neonatal period and in case of prematurity.