Last update Dec. 2, 2022

Проглуметацина Малеат

Likely Compatibility

Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.

Nonsteroidal anti-inflammatory drug (NSAID) derived from indomethacin-related indoleacetic acid. It is a pro-drug of indomethacin conjugated with proglumide, a gastric protector that inhibits gastric secretion by being an antagonist of cholecystokinin. It has been used in musculoskeletal and joint disorders. Oral, rectal and topical cream administration at 5%.

At the date of the last update, the authors did not find any published data on its excretion in breast milk.

Although it has a high molecular weight that would hinder its excretion in breast milk, the absence of published pharmacokinetic data does not allow its excretion in breast milk to be predicted.

Product with very few and/or very old bibliographic references, marketed in few countries.

Safer known alternatives are preferable during breastfeeding, especially during the neonatal period and in case of prematurity.


Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Проглуметацина Малеат is Proglumetacin Maleate in Cyrillic.

Is written in other languages:

Проглуметацина Малеат is also known as


Проглуметацина Малеат belongs to this group or family:


Main tradenames from several countries containing Проглуметацина Малеат in its composition:


Variable Value Unit
Molecular weight 1.077 daltons
pKa 15.4 -
Tmax 5.46 ± 0.17 hours
10 hours


  1. Bignamini AA, Casula PL. Preliminary bioavailability study on protacine: a new, non-steroidal anti-inflammatory agent. Curr Med Res Opin. 1979;6(4):299-302. Abstract

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