Last update Dec. 2, 2022

Proglumetacin Maleate

Low Risk

Possibly safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.

Nonsteroidal anti-inflammatory drug (NSAID) derived from indomethacin-related indoleacetic acid. It is a pro-drug of indomethacin conjugated with proglumide, a gastric protector that inhibits gastric secretion by being an antagonist of cholecystokinin. It has been used in musculoskeletal and joint disorders. Oral, rectal and topical cream administration at 5%.

At the date of the last update, the authors did not find any published data on its excretion in breast milk.

Although it has a high molecular weight that would hinder its excretion in breast milk, the absence of published pharmacokinetic data does not allow its excretion in breast milk to be predicted.

Product with very few and/or very old bibliographic references, marketed in few countries.

Safer known alternatives are preferable during breastfeeding, especially during the neonatal period and in case of prematurity.

Alternatives

  • Dexibuprofen ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Diclofenac ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Indomethacin; Indometacin ( Safe. Compatible. Minimal risk for breastfeeding and infant.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Proglumetacin Maleate is also known as


Proglumetacin Maleate in other languages or writings:

Group

Proglumetacin Maleate belongs to this group or family:

Tradenames

Main tradenames from several countries containing Proglumetacin Maleate in its composition:

Pharmacokinetics

Variable Value Unit
Molecular weight 1.077 daltons
pKa 15.4 -
Tmax 5.46 ± 0.17 hours
10 hours

References

  1. Bignamini AA, Casula PL. Preliminary bioavailability study on protacine: a new, non-steroidal anti-inflammatory agent. Curr Med Res Opin. 1979;6(4):299-302. Abstract

Total visits

4,346

Help us improve this entry

How to cite this entry

Do you need more information or did not found what you were looking for?

   Write us at elactancia.org@gmail.com

e-lactancia is a resource recommended by Asociación Española de Bancos de Leche Humana of Spain

Would you like to recommend the use of e-lactancia? Write to us at corporate mail of APILAM