Last update Sept. 4, 2022
Typical, first-generation antipsychotic. Prochlorperazine is a phenothiazine derivative with general properties similar to those of chlorpromazine. It is used in the prevention and treatment of nausea and vomiting, vertigo, schizophrenia, bipolar disorder, and severe anxiety. Oral, rectal or parenteral administration two to three times a day.
Since the last update we have not found published data on its excretion in breastmilk.
Its pharmacokinetic data (very wide volume of distribution (Taylor 1987) and high percentage of protein binding) make it highly unlikely that significant quantities will pass into breast milk.
Its very low oral bioavailability (Isah 1992, Taylor 1987) makes it difficult for it to pass to the infant plasma from ingested breast milk, except in premature infants and in the immediate neonatal period in which there may be greater intestinal permeability.
Some cases of galactorrhea have been described. (Hooper 1961)
Various medical societies and expert authors consider the punctual use of this medication to be safe during breastfeeding. (LactMed, Worthington 2013)
Until more published data is known about this drug in relation to breastfeeding, known safer alternatives are preferable (Hale, Reece 2017, Parikh 2014, Mahadevan 2006, Lee 1993), especially during the neonatal period and in the event of prematurity.
Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.
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e-lactancia is a resource recommended by Asociación Pro Lactancia Materna (APROLAM) of Mexico
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