Last update May 20, 2024
Compatible
Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.
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Празозина Гидрохлорид is Prazosin Hydrochloride in Greek.
Is written in other languages:Празозина Гидрохлорид is also known as
Празозина Гидрохлорид belongs to these groups or families:
Variable | Value | Unit |
---|---|---|
Oral Bioavail. | 40 - 68 | % |
Molecular weight | 420 | daltons |
Protein Binding | 95 | % |
VD | 0.6 | l/Kg |
pKa | 7.2 | - |
Tmax | 3 | hours |
T½ | 2 - 3 | hours |
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e-lactancia is a resource recommended by Academy of Breastfeeding Medicine - 2015 of United States of America
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An antihypertensive and antiadrenergic agent with peripheral action indicated in the treatment of hypertension and Raynaud's phenomenon. Oral administration in two daily doses.
According to the manufacturer, it is excreted in small amount in breast milk (Pfizer 2016 & 2009), with a relative dose of at most 3%. (Schaefer 2015, p 716)
Its pharmacokinetic data - large volume of distribution, high percentage of protein binding and short half-life (Pfizer 2016, Kirsten 1998)-, makes transfer into breastmilk in significant quantities unlikely.
Its low oral bioavailability hinders transfer to infant plasma from breastmilk, except in premature infants and the immediate neonatal period when there may be increased intestinal permeability.
It is structurally similar to doxazosin, which is excreted in breast milk in negligible amounts.
There is contradictory data regarding its action on prolactin, not affecting its levels according to some (Laakmann 1986, Barbieri 1980) or decreasing it according to others (Gumbatov 1992), but when breastfeeding is well established, milk production does not depend as much on levels of prolactin.(Messinis 1985).
Until there is more published data on this drug in relation to breastfeeding, safer known alternatives may be preferable (Anderson 2018, Malachias 2018, Schaefer 2007 p685), especially during the neonatal period and in cases of prematurity.