Last update July 25, 2022
Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.
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Prazosin Hydrochloride is also known as
Prazosin Hydrochloride in other languages or writings:
Prazosin Hydrochloride belongs to these groups or families:
|Oral Bioavail.||40 - 68||%|
|T½||2 - 3||hours|
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e-lactancia is a resource recommended by Asociación Española de Bancos de Leche Humana of Spain
Would you like to recommend the use of e-lactancia? Write to us at corporate mail of APILAM
An antihypertensive and antiadrenergic agent with peripheral action indicated in the treatment of hypertension and Raynaud's phenomenon. Oral administration in two daily doses.
Since the last update we have not found any published data on its excretion in breast milk.
Its pharmacokinetic data - large volume of distribution, high percentage of protein binding and short half-life (Pfizer 2016, Kirsten 1998)-, makes transfer into breastmilk in significant quantities unlikely.
Its low oral bioavailability hinders transfer to infant plasma from breastmilk, except in premature infants and the immediate neonatal period when there may be increased intestinal permeability.
It is structurally similar to doxazosin, which is excreted in breast milk in negligible amounts.
There is contradictory data regarding its action on prolactin, not affecting its levels according to some (Laakmann 1986, Barbieri 1980) or decreasing it according to others (Gumbatov 1992), but when breastfeeding is well established, milk production does not depend as much on levels of prolactin.(Messinis 1985).
Until there is more published data on this drug in relation to breastfeeding, safer known alternatives may be preferable (Anderson 2018, Malachias 2018, Schaefer 2007 p685), especially during the neonatal period and in cases of prematurity.