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Factor VII is a vitamin K-dependent plasma glycoprotein consisting of 406 amino acids. It is involved in blood coagulation. It can be obtained from human plasma or produced by recombinant DNA technology (Eptacog Alfa). It is used to treat bleeding disorders such as hemophilia, Glanzmann's thrombasthenia, and congenital factor VII deficiency, and in the treatment of severe postpartum hemorrhage unresponsive to uterotonics. Intravenous administration.
Since the last update we have not found published data on its excretion in breastmilk.
Its very high molecular weigh and its binding to coagulation factors X and IX and tissue factor make it highly unlikely that significant quantities will pass into breast milk.
Due to its protein nature, it is inactivated in the gastrointestinal tract, and is not absorbed, (it has virtually no oral bioavailability), which hinders or prevents its transfer from breastmilk to infant, except in premature babies and the immediate neonatal period, when there may be greater intestinal permeability.
Expert authors consider the use of this medication probably compatible during breastfeeding. (Hale). Recommendations for Drugs in the Eleventh WHO Model List of Essential Drugs: compatible with Breastfeeding. (WHO 2002)