Last update June 9, 2018

Phenindione

Incompatible

Very unsafe. Contraindicated. Use of an alternative or cessation of breastfeeding. Read the Commentary.

An anticoagulant derived from indandione. Vitamin K antagonist.
Administered orally.
Used less and less due to its serious side effects, which is why it has been withdrawn from sale in many countries (AAP 2001).

It is excreted in breastmilk in significant amounts (Goguel 1970).

There is a published a case of severe scrotal hematoma after surgical intervention (herniorrhaphy) in an infant whose mother was being treated with phenindione (Eckstein 1970).

Alternatives

  • Dicumarol (Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.)
  • Warfarin (Safe product and/or breastfeeding is the best option.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

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Other names

Phenindione is also known as


Phenindione in other languages or writings:

Group

Phenindione belongs to this group or family:

Tradenames

Main tradenames from several countries containing Phenindione in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 100 %
Molecular weight 222 daltons
Protein Binding 88 %
Tmax 1.3 hours
T½ 5 - 6 hours
Theoretical Dose 0.15 - 0.75 mg/Kg/d
Relative Dose 12 - 60 %

References

  1. AAP - American Academy of Pediatrics Committee on Drugs. Transfer of drugs and other chemicals into human milk. Pediatrics. 2001 Sep;108(3):776-89. Abstract Full text (link to original source) Full text (in our servers)
  2. Stabin MG, Breitz HB. Breast milk excretion of radiopharmaceuticals: mechanisms, findings, and radiation dosimetry. J Nucl Med. 2000 Abstract Full text (link to original source) Full text (in our servers)
  3. Eckstein HB, Jack B. Breast-feeding and anticoagulant therapy. Lancet. 1970 Abstract
  4. Goguel M, Noël G, Gillet JY, Girardel JM, Muller P, Mayer G. Thérapeutique anticoagulante et allaitement: etude du passage de la phényl-2-dioxo, 1,3 indane dans le lait maternel. [Anticoagulant therapy and breast-feeding: study of the passage of phenyl-2-dioxo, 1,3 indane in the maternal milk]. Rev Fr Gynecol Obstet. 1970 Abstract

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