Last update Dec. 21, 2021

Флудрокортизона Ацетат

Likely Compatibility

Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.

Steroidal drug with glucocorticoid action and high activity as mineralocorticoid. Systemic administration: oral route. Indicated as replacement therapy in Adrenal Insufficiency (Addison’s Disease) and "salt-losing" Congenital Adrenal Hyperplasia. Topical administration: creams as dermatologic compounds and eye drops for ophthalmologic use.

At latest update relevant published data were not found on excretion into breast milk.


Other corticosteroids are know to be excreted into breastmilk in small amounts.

Since the goal of treatment is to keep the mother within normal plasma hormone ranges, by monitoring adequately through analytical controls to make sure the mother is receiving a correct dose, it would neither interfere with breastfeeding nor would be harmful to the infant.

Take as lowest effective dose as possible with follow-up the infant for hypo-adrenal signs.

TOPICAL ADMINISTRATION (dermatologic and ophthalmologic use):

The small dose used along with a poor passage to plasma of most ophthalmologic and topical dermatologic preparations makes it very unlikely that a significant excretion into breastmilk would occur.

Do not apply on the breast to prevent ingestion by the infant; otherwise, do it just after a meal and clean the nipple thoroughly with water before the next feed.

Mineral-corticoid poisoning occurred in an infant after long-term application of a corticoid cream on the nipple. (De Stefano 1983)


We do not have alternatives for

Флудрокортизона Ацетат


Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Флудрокортизона Ацетат

is Fludrocortisone Acetate in Cyrillic.

Is written in other languages:

Флудрокортизона Ацетат

is also known as


Флудрокортизона Ацетат

belongs to these groups or families:


Main tradenames from several countries containing

Флудрокортизона Ацетат

in its composition:


Variable Value Unit
Oral Bioavail. 93 %
Molecular weight 423 daltons
Protein Binding 70 - 80 %
VD 1.1 l/Kg
pKa 12.55 -
Tmax 0.5 - 1.7 hours
1.3 - 3.5 hours


  1. Polito A, Hamitouche N, Ribot M, Polito A, Laviolle B, Bellissant E, Annane D, Alvarez JC. Pharmacokinetics of oral fludrocortisone in septic shock. Br J Clin Pharmacol. 2016 Abstract
  2. AEMPS. Fludrocortisona. Ficha técnica. 2016 Full text (in our servers)
  3. ASPEN. Fludrocortisone. Drug Summary. 2015 Full text (in our servers)
  4. Merck Fludrocortison. Drogen Zusammenfassung. 2014 Full text (in our servers)
  5. De Stefano P, Bongo IG, Borgna-Pignatti C, Severi F. Factitious hypertension with mineralocorticoid excess in an infant. Helv Paediatr Acta. 1983 Abstract

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