Last update Dec. 21, 2021

Fludrocortisone Acetate

Low Risk

Possibly safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.

Steroidal drug with glucocorticoid action and high activity as mineralocorticoid. Systemic administration: oral route. Indicated as replacement therapy in Adrenal Insufficiency (Addison’s Disease) and "salt-losing" Congenital Adrenal Hyperplasia. Topical administration: creams as dermatologic compounds and eye drops for ophthalmologic use.

At latest update relevant published data were not found on excretion into breast milk.

SYSTEMIC ADMINISTRATION:

Other corticosteroids are know to be excreted into breastmilk in small amounts.

Since the goal of treatment is to keep the mother within normal plasma hormone ranges, by monitoring adequately through analytical controls to make sure the mother is receiving a correct dose, it would neither interfere with breastfeeding nor would be harmful to the infant.

Take as lowest effective dose as possible with follow-up the infant for hypo-adrenal signs.

TOPICAL ADMINISTRATION (dermatologic and ophthalmologic use):

The small dose used along with a poor passage to plasma of most ophthalmologic and topical dermatologic preparations makes it very unlikely that a significant excretion into breastmilk would occur.

Do not apply on the breast to prevent ingestion by the infant; otherwise, do it just after a meal and clean the nipple thoroughly with water before the next feed.

Mineral-corticoid poisoning occurred in an infant after long-term application of a corticoid cream on the nipple. (De Stefano 1983)

Alternatives

We do not have alternatives for Fludrocortisone Acetate.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Fludrocortisone Acetate is also known as


Fludrocortisone Acetate in other languages or writings:

Tradenames

Main tradenames from several countries containing Fludrocortisone Acetate in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 93 %
Molecular weight 423 daltons
Protein Binding 70 - 80 %
VD 1.1 l/Kg
pKa 12.55 -
Tmax 0.5 - 1.7 hours
1.3 - 3.5 hours

References

  1. Polito A, Hamitouche N, Ribot M, Polito A, Laviolle B, Bellissant E, Annane D, Alvarez JC. Pharmacokinetics of oral fludrocortisone in septic shock. Br J Clin Pharmacol. 2016 Abstract
  2. AEMPS. Fludrocortisona. Ficha técnica. 2016 Full text (in our servers)
  3. ASPEN. Fludrocortisone. Drug Summary. 2015 Full text (in our servers)
  4. Merck Fludrocortison. Drogen Zusammenfassung. 2014 Full text (in our servers)
  5. De Stefano P, Bongo IG, Borgna-Pignatti C, Severi F. Factitious hypertension with mineralocorticoid excess in an infant. Helv Paediatr Acta. 1983 Abstract

Total visits

21,227

Help us improve this entry

How to cite this entry

Do you need more information or did not found what you were looking for?

   Write us at elactancia.org@gmail.com

e-lactancia is a resource recommended by Asociación Española de Bancos de Leche Humana of Spain

Would you like to recommend the use of e-lactancia? Write to us at corporate mail of APILAM