Last update Dec. 4, 2020

Oseltamivir Phosphate

Compatible

Safe substance and/or breastfeeding is the best option.

Inhibitor of the enzyme neuraminidase (sialidase), indicated in the treatment and prophylaxis of influenza.
Oral administration in two daily doses.

It is excreted in breastmilk in clinically insignificant amounts (Greer 2011, Wentges 2008), much lower than the dose used in newborns and infants (Greer 2011, Kanmaz 2011).

It has been used in newborns (Kanmaz 2010).

Various medical associations and expert consensus consider its use to be safe during breastfeeding (Dembinski 2010, Skalli 2010, Chen 2010, Tanaka 2009, ABM 2009, AEM 2009, Satpathy 2009).

Alternatives

We do not have alternatives for Oseltamivir Phosphate since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Other names

Oseltamivir Phosphate in other languages or writings:

Group

Oseltamivir Phosphate belongs to this group or family:

Tradenames

Main tradenames from several countries containing Oseltamivir Phosphate in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 75 %
Molecular weight 410 daltons
Protein Binding 3 - 42 %
VD 0.38 l/Kg
pKa 14.03 -
T½ 6 - 10 hours
Theoretical Dose 0.012 mg/Kg/d
Relative Dose 0.6 %
Ped.Relat.Dose 0.3 - 0.6 %

References

  1. Kanmaz G, Erdeve O, Oguz SS, Uras N, Dilmen U. Influenza a (H1N1) virus pneumonia in newborns: experience of a referral level III neonatal intensive care unit in Turkey. Pediatr Pulmonol. 2011 Feb;46(2):201-2; author reply 203. Abstract
  2. Greer LG, Leff RD, Rogers VL, Roberts SW, McCracken GH Jr, Wendel GD Jr, Sheffield JS. Pharmacokinetics of oseltamivir in breast milk and maternal plasma. Am J Obstet Gynecol. 2011 Abstract Full text (link to original source) Full text (in our servers)
  3. Dembinski J. [Oseltamivir in pregnancy, lactation and neonatal period--comparison of international recommendations]. Z Geburtshilfe Neonatol. 2010 Abstract
  4. Skalli S, Ferreira E, Bussières JF, Allenet B. Grippe A/H1N1v 2009, grossesse et allaitement: quel antiviral choisir? [Influenza A/H1N1v 2009 during pregnancy and breastfeeding: which antiviral to choose?]. Ann Pharm Fr. 2010 Abstract
  5. Chen LH, Zeind C, Mackell S, LaPointe T, Mutsch M, Wilson ME. Breastfeeding travelers: precautions and recommendations. J Travel Med. 2010 Jan-Feb;17(1):32-47. Abstract Full text (link to original source) Full text (in our servers)
  6. Academy of Breastfeeding Medicine. Breastfeeding / Swine Flu Recommendations for Physicians from the Academy of Breastfeeding Medicine For immediate release (ABM) 2009 Full text (in our servers)
  7. Tanaka T, Nakajima K, Murashima A, Garcia-Bournissen F, Koren G, Ito S. Safety of neuraminidase inhibitors against novel influenza A (H1N1) in pregnant and breastfeeding women. CMAJ. 2009 Abstract Full text (link to original source) Full text (in our servers)
  8. Agencia Europea del Medicamento (EMA) Oseltamivir Ficha técnica 2009 Full text (in our servers)
  9. Agencia Española del Medicamento Uso de Oseltamivir y Zanamivir en niños de cualquier edad, en mujeres gestantes y mujeres en periodo de lactancia y en personas con problemas de deglución. \ Nota Informativa 2009 Full text (in our servers)
  10. Satpathy HK, Lindsay M, Kawwass JF. Novel H1N1 virus infection and pregnancy. Postgrad Med. 2009 Nov;121(6):106-12. Abstract
  11. Wentges-van Holthe N, van Eijkeren M, van der Laan JW. Oseltamivir and breastfeeding. Int J Infect Dis. 2008 Abstract Full text (link to original source) Full text (in our servers)

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