Last update April 15, 2024

νισολδιπίνη

Low Risk

Possibly safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.

It is a dihydropyridine-type calcium channel blocker with actions similar to those of nifedipine. It is used in the treatment of hypertension and angina pectoris. Oral administration one or twice daily.

At latest update no published data were found on excretion into breast milk.

Its high plasma protein binding capacity and very wide volume of distribution makes it highly unlikely a passage into breast milk.

Its very low oral bioavailability minimizes the passage into plasma of the infant from ingested breast milk, except in the premature and in the immediate neonatal period in which there may be greater intestinal permeability.

Evidence on other antihypertensive drugs of the same family with similar structure, pharmacokinetics and action profile (nifedipine, nimodipine, nicardipine) has shown that they are excreted into milk in non-significant amount.

Expert authors consider the use of this medication possible during breastfeeding. (Hale, Malachias 2016, Briggs 2015)

Until more extensive published data about this drug regarding breastfeeding are available a safer alternative drug should be used, especially during the neonatal period and/or in case of premature infants.

Alternatives

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

νισολδιπίνη is Nisoldipine in Greek.

Is written in other languages:

Groups

νισολδιπίνη belongs to these groups or families:

Tradenames

Main tradenames from several countries containing νισολδιπίνη in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 5 (4 - 8( %
Molecular weight 388 daltons
Protein Binding 99 %
VD 5.9 l/Kg
pKa 16.94 -
Tmax 0.5 - 2 hours
7 - 12 hours

References

  1. Hale TW. Medications & Mothers' Milk. 1991- . Springer Publishing Company. Available from https://www.halesmeds.com Consulted on April 10, 2024 Full text (link to original source)
  2. Malachias MV, Figueiredo CE, Sass N, Antonello IC, Torloni MR, Bortolotto MRF L. 7th Brazilian Guideline of Arterial Hypertension: Chapter 9 - Arterial Hypertension in pregnancy Arq Bras Cardiol. 2016 Abstract Full text (link to original source) Full text (in our servers)
  3. Briggs GG, Freeman RK, Towers CV, Forinash AB. Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk. Wolters Kluwer Health. Tenth edition (acces on line) 2015
  4. AEMPS. Nisoldipino. Ficha técnica. 2004 Full text (in our servers)
  5. van Harten J, van Brummelen P, Danhof M, Quekel RP, Breimer DD. Pharmacokinetics and hemodynamic effects of long-term nisoldipine treatment in hypertensive patients. J Cardiovasc Pharmacol. 1989 Abstract

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