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It is a dihydropyridine-type calcium channel blocker with actions similar to those of nifedipine. It is used in the treatment of hypertension and angina pectoris. Oral administration one or twice daily.
At latest update no published data were found on excretion into breast milk.
Its high plasma protein binding capacity and very wide volume of distribution makes it highly unlikely a passage into breast milk.
Its very low oral bioavailability minimizes the passage into plasma of the infant from ingested breast milk, except in the premature and in the immediate neonatal period in which there may be greater intestinal permeability.
Evidence on other antihypertensive drugs of the same family with similar structure, pharmacokinetics and action profile (nifedipine, nimodipine, nicardipine) has shown that they are excreted into milk in non-significant amount.
Expert authors consider the use of this medication possible during breastfeeding. (Hale, Malachias 2016, Briggs 2015)
Until more extensive published data about this drug regarding breastfeeding are available a safer alternative drug should be used, especially during the neonatal period and/or in case of premature infants.