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It is an antidepressant structurally related to trazodone. Oral administration in two daily doses.
Its pharmacokinetic data (high percentage of protein binding, large volume of distribution and moderately high molecular weight) explain the negligible passage into breast milk observed. (Yapp 2000, Dodd 2000 & 1999)
However, a 9-week-old, 27-week-premature infant whose mother was taking nefazodone had drowsiness, lethargy, growth retardation, and hypothermia. (Gjerdingen 2003, Yapp 2000)
Until more published data is known about this drug in relation to breastfeeding, known safer alternatives are preferable (Davanzo 2011), especially during the neonatal period and in the event of prematurity.
Withdrawn from market in many countries because an increased risk of a rather rare but severe hepatotoxicity. (Choi 2003)