Last update May 22, 2025

Натрий Цефалотин

Likely Compatibility

Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.

First-generation cephalosporin antibiótic. Injectable, parenteral administration.

At latest update no published data on excretion into breast milk were found.

Its moderately high molecular weight and short half-life make passage into milk of significant amounts unlikely.

Most cephalosporins are excreted into milk in insignificant amounts from a therapeutic point of view (Rowe 2013, Fulton 1992, Matsuda 1984, Kafetzis 1981) without reported complications in infants.

Cephalosporins are widely used in the Pediatric practice with a good tolerance, even in the neonatal period, so it is very unlikely that in small amounts through milk would be a cause of problems in the infant.

Be aware of the possibility of gastroenteritis (Ito 1993) by altering the intestinal flora.

Several medical societies and expert authors consider it safe to use this medication during breastfeeding. (Silveira 2020)

Alternatives

  • Cefadroxil (Safe product and/or breastfeeding is the best option.)
  • Ceftibuten (Safe product and/or breastfeeding is the best option.)
  • Cephalexin (Safe product and/or breastfeeding is the best option.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Other names

Натрий Цефалотин is Cefalotin Sodium, Cephalothin in Cyrillic.

Is written in other languages:

Group

Натрий Цефалотин belongs to this group or family:

Tradenames

Main tradenames from several countries containing Натрий Цефалотин in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. Baja - Poor %
Molecular weight 418 daltons
Protein Binding 65 - 80 %
Tmax 0.5 hours
T½ 0.5 - 0.8 hours
M/P ratio 0.6 -
Theoretical Dose 0.07 mg/Kg/d
Relative Dose 0.2 %
Ped.Relat.Dose 0.04 - 0.1 %

References

  1. Silveira MPT, Possignollo J, Miranda VIA, Silveira MFD, Pizzol TDSD, Serrate S, Bertoldi AD. Breastfeeding and risk classification of medications used during hospitalization for delivery: 2015 Pelotas Birth Cohort. Rev Bras Epidemiol. 2020;23:e200026. Abstract Full text (link to original source)
  2. van Wattum JJ, Leferink TM, Wilffert B, Ter Horst PGJ. Antibiotics and lactation: An overview of relative infant doses and a systematic assessment of clinical studies. Basic Clin Pharmacol Toxicol. 2019 Jan;124(1):5-17. Abstract
  3. Butler DC, Heller MM, Murase JE. Safety of dermatologic medications in pregnancy and lactation: Part II. Lactation. J Am Acad Dermatol. 2014 Mar;70(3):417.e1-10; quiz 427. Abstract
  4. Rowe H, Baker T, Hale TW. Maternal medication, drug use, and breastfeeding. Pediatr Clin North Am. 2013 Feb;60(1):275-94. Abstract
  5. Amir LH, Pirotta MV, Raval M. Breastfeeding--evidence based guidelines for the use of medicines. Aust Fam Physician. 2011 Sep;40(9):684-90. Review. Abstract
  6. Ito S, Blajchman A, Stephenson M, Eliopoulos C, Koren G. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993 May;168(5):1393-9. Abstract
  7. Fulton B, Moore LL. Antiinfectives in breastmilk. Part I: Penicillins and cephalosporins. J Hum Lact. 1992 Abstract
  8. Matsuda S. Transfer of antibiotics into maternal milk. Biol Res Pregnancy Perinatol. 1984;5(2):57-60. Abstract
  9. Kafetzis DA, Siafas CA, Georgakopoulos PA, Papadatos CJ. Passage of cephalosporins and amoxicillin into the breast milk. Acta Paediatr Scand. 1981 Abstract

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