Last update Aug. 22, 2019
Very Low Risk
We do not have alternatives for N01BB08 since it is relatively safe.
Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.
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N01BB08 is Articaine Hydrochloride in ATC Code/s.Is written in other languages:
N01BB08 is also known as
N01BB08 belongs to this group or family:
Main tradenames from several countries containing N01BB08 in its composition:
|Oral Bioavail.||baja - poor||%|
|Protein Binding||53 - 73||%|
|VD||1.67 - 2.69||l/Kg|
|T½||0.3 (epidural: 0.5 - 2.2)||hours|
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e-lactancia is a resource recommended by Asociación Pro Lactancia Materna (APROLAM) of Mexico
Would you like to recommend the use of e-lactancia? Write to us at corporate mail of APILAM
Amide-type local anesthetic, usually associated with epinephrine, used in dental, local and regional anesthesia (infiltration and epidural).
Since the last update we have not found published data in relation to breastfeeding.
It is immediately hydrolyzed to inactive articainic acid (van Oss 1989 and 1988), so no systemic toxicity is observed (AEMPS 2019, FDA 2006), even after unintentional systemic injection (Oertel 1997).
In addition, its short elimination half-life and wide distribution volume would prevent excretion in breastmilk in significant quantities.
According to the manufacturer, it is not necessary to stop breastfeeding since there are no clinically relevant levels in breastmilk (AEMPS 2019).
If ingested orally, it is rapidly hydrolyzed by gastric esterases, which would prevent it from reaching the infant's plasma from breastmilk (Hale 2019).
Due to its characteristics, it is the local anesthetic of choice during breastfeeding for dental and infiltration procedures (Nizharadze 2011).
See below the information of this related product: