Last update Aug. 22, 2019

Methyl 4-methyl-3-(2-propylaminopropionamido)thiophene-2-carboxylate hydrochloride

Very Low Risk

Safe. Compatible. Minimal risk for breastfeeding and infant.

Amide-type local anesthetic, usually associated with epinephrine, used in dental, local and regional anesthesia (infiltration and epidural).

Since the last update we have not found published data in relation to breastfeeding.

It is immediately hydrolyzed to inactive articainic acid (van Oss 1989 and 1988), so no systemic toxicity is observed (AEMPS 2019, FDA 2006), even after unintentional systemic injection (Oertel 1997).

In addition, its short elimination half-life and wide distribution volume would prevent excretion in breastmilk in significant quantities.

According to the manufacturer, it is not necessary to stop breastfeeding since there are no clinically relevant levels in breastmilk (AEMPS 2019).

If ingested orally, it is rapidly hydrolyzed by gastric esterases, which would prevent it from reaching the infant's plasma from breastmilk (Hale 2019).

Due to its characteristics, it is the local anesthetic of choice during breastfeeding for dental and infiltration procedures (Nizharadze 2011).


See below the information of this related product:

Alternatives

We do not have alternatives for Methyl 4-methyl-3-(2-propylaminopropionamido)thiophene-2-carboxylate hydrochloride since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Other names

Methyl 4-methyl-3-(2-propylaminopropionamido)thiophene-2-carboxylate hydrochloride is Articaine Hydrochloride in Chemical name.

Is written in other languages:

Methyl 4-methyl-3-(2-propylaminopropionamido)thiophene-2-carboxylate hydrochloride is also known as

Group

Methyl 4-methyl-3-(2-propylaminopropionamido)thiophene-2-carboxylate hydrochloride belongs to this group or family:

Tradenames

Main tradenames from several countries containing Methyl 4-methyl-3-(2-propylaminopropionamido)thiophene-2-carboxylate hydrochloride in its composition:

List of 30 tradenames

Pharmacokinetics

Variable Value Unit
Oral Bioavail. baja - poor %
Molecular weight 321 daltons
Protein Binding 53 - 73 %
VD 1.67 - 2.69 l/Kg
pKa 4.42 -
Tmax 0.25 hours
T½ 0.3 (epidural: 0.5 - 2.2) hours

References

  1. AEMPS - Normon. Articaína (Ultracaín). Ficha técnica. 2019 Full text (in our servers)
  2. Nizharadze N, Mamaladze M, Chipashvili N, Vadachkoria D. Articaine - the best choice of local anesthetic in contemporary dentistry. Georgian Med News. 2011 Abstract
  3. FDA. Artisane (Septocaine). Drug Summary. 2006 Full text (in our servers)
  4. Oertel R, Rahn R, Kirch W. Clinical pharmacokinetics of articaine. Clin Pharmacokinet. 1997 Abstract
  5. van Oss GE, Vree TB, Baars AM, Termond EF, Booij LH. Pharmacokinetics, metabolism, and renal excretion of articaine and its metabolite articainic acid in patients after epidural administration. Eur J Anaesthesiol. 1989 Abstract
  6. Van Oss GE, Vree TB, Baars AM, Termond EF, Booij LH. Clinical effects and pharmacokinetics of articainic acid in one volunteer after intravenous administration. Pharm Weekbl Sci. 1988 Abstract

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