Last update Jan. 17, 2022
Limited compatibility
Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.
Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.
Thank you for helping to protect and promote breastfeeding.
Milrinone is also known as
Milrinone in other languages or writings:
Variable | Value | Unit |
---|---|---|
Oral Bioavail. | 80 | % |
Molecular weight | 211 | daltons |
Protein Binding | 70 | % |
VD | 0.38 - 0.45 | l/Kg |
pKa | 7.54 | - |
Tmax | 0.03 - 0.08 | hours |
T½ | 2.3 | hours |
Write us at elactancia.org@gmail.com
e-lactancia is a resource recommended by Academy of Breastfeeding Medicine - 2015 of United States of America
Would you like to recommend the use of e-lactancia? Write to us at corporate mail of APILAM
Amrinone is a phosphodiesterase type 3 inhibitor, similar to milrinone, with positive vasodilator and inotropic properties. Indicated in the treatment of heart failure. Intravenous administration (oral administration has too many side effects).
Since the last update we have not found any published data on its excretion in breast milk.
Its pharmacokinetic data (low molecular weigh and low protein binding) make it likely that it would pass into breast milk in amounts which could be significant.
Milrinone and amrinone have a slower elimination rate in newborns and young infants and a higher risk of potentially serious side effects. (Sanofi 2016, Laitinen 2000, Ramamoorthy 1998)
Until more published data is known about this drug in relation to breastfeeding, known safer alternatives are preferable (Kearney 2018), especially during the neonatal period and in the event of prematurity.
If used during lactation: express and discard breast milk and wait to breastfeed 8 to 10 hours after administration.
See below the information of this related product: