Last update May 18, 2022

Mianserin Hydrochloride

Low Risk

Moderately safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.

Tetracyclic antidepressant with marked sedative action. Inhibits norepinephrine reuptake.

Single nightly dose oral administration.

It is excreted in human milk in a clinically insignificant amount and the plasma or urine levels of infants whose mothers took it were either very low or below the limit of detection. (Buist 1993)

It is not recommended to share a bed with the baby if this drug is being taken. (UNICEF 2018, 2017, 2014 and 2013, Landa 2012, ABM 2008, UNICEF 2006)

Due to the sedative action on the mother and because there is less published experience than with other antidepressant drugs, known safer alternatives might be preferable, especially during the neonatal period and in the event of prematurity.


See below the information of these related products:

  • Maternal Depression (Moderately safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.)
  • Mirtazapine ( Safe. Compatible. Minimal risk for breastfeeding and infant.)

Alternatives

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Mianserin Hydrochloride in other languages or writings:

Group

Mianserin Hydrochloride belongs to this group or family:

Tradenames

Main tradenames from several countries containing Mianserin Hydrochloride in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 20 - 30 %
Molecular weight 301 daltons
Protein Binding 90 %
Tmax 3 hours
40 (21 - 61) hours
M/P ratio 3.6 -
Theoretical Dose 0.003 - 0.012 mg/Kg/d
Relative Dose 0.5 - 1.4 %

References

  1. UNICEF UK. Caring for your baby at night. A guide for parents. 2018 Full text (link to original source) Full text (in our servers)
  2. UNICEF. Ball H, Blair PS. (For UNICEF UK). Caring for your baby at night. Health professional´s guide. 2017 Full text (link to original source) Full text (in our servers)
  3. UNICEF UK. Statement on co-sleeping following publication of new NICE postnatal guidance. Infosheet. 2014 Full text (link to original source) Full text (in our servers)
  4. UNICEF UK Baby Friendly Initiative statement on Bed-sharing when parents do not smoke: is there a risk of SIDS? An individual level analysis of five major case-control studies. None 2013 Full text (link to original source) Full text (in our servers)
  5. L.Landa Rivera, M.Díaz-Gómez, A.Gómez Papi, J.M.Paricio Talayero, C.Pallás Alonso, M.T.Hernández Aguilar, J.Aguayo Maldonado, J.M.Arena Ansotegui, S.Ares Segura, A.Jiménez Moya, J.J.Lasarte Velillas, J.Martín Calama, M.D.Romero Escós. El colecho favorece la práctica de la lactancia materna y no aumenta el riesgo de muerte súbita del lactante. Dormir con los padres. Rev Pediatr Aten Primaria. 14:53-60 2012 Full text (link to original source) Full text (in our servers)
  6. ABM - The Academy of Breastfeeding Medicine Protocol Committee. ABM Clinical Protocol #6: Guideline on Co-Sleeping and Breastfeeding. Breastfeeding Medicine 2008 Abstract Full text (link to original source) Full text (in our servers)
  7. ABM - Comité de protocolos de la Academia médica de lactancia materna (Academy of Breastfeeding Medicine). Protocolo Clínico de la ABM #6: Lineamientos sobre la práctica de dormir al bebé junto con la madre y la lactancia materna Revisión, marzo de 2008. Breastfeeding Medicine 2008 Full text (link to original source) Full text (in our servers)
  8. UNICEF UK. Compartiendo la cama con tu bebé. Guía para madres que amamantan. Folleto 2006 Full text (in our servers)
  9. Buist A, Norman TR, Dennerstein L. Mianserin in breast milk. Br J Clin Pharmacol. 1993 Aug;36(2):133-4. No abstract available. Abstract

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