Last update March 29, 2023

Meglumine Metrizoate

Very Low Risk

Safe. Compatible. Minimal risk for breastfeeding and infant.

The X-ray contrast media with components like Metrizoic acid, Meglumine and Sodium have a content between 52 and 60% of Iodine. It has been withhold from the market.

Metrizoate is excreted into breast milk in clinically non-significant amount: 0.3% of the maternal dose. (Nielsen, 1987)

The various Iodinated contrast media for imaging examinations (X-rays, CT scans) are considered compatible with breastfeeding since they are rapidly eliminated with little or no release of iodine, not metabolized and virtually not absorbed when taken by mouth. They are structurally very similar to each other and one of them is their data no or minimal excretion in milk.

Given the low lipid solubility of the iodinated contrast, less than 1% of the dose administered to the mother just passing milk. Due to their low oral bioavailability, intestinal absorption is less than 1% of the dose that he may take the infant. The maximum dose just getting the baby is less than 0.01% of the maternal dose, which represents less than 1% of the dose administered to a nursing practice that is a radiological contrast examination.

Most experts and radiology scientific societies agree that after a radiological iodinated contrast examination is not necessary to wait no time to nurse.

American Academy of Pediatrics: medication usually compatible with breastfeeding.(AAP 2001)


See below the information of this related product:

Alternatives

We do not have alternatives for Meglumine Metrizoate since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Meglumine Metrizoate is also known as


Meglumine Metrizoate in other languages or writings:

Group

Meglumine Metrizoate belongs to this group or family:

Tradenames

Main tradenames from several countries containing Meglumine Metrizoate in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 0 %
Molecular weight 628 - 823 daltons
Protein Binding 5 %
pKa 2.16 -
1 - 2 hours
Theoretical Dose 2.1 mg/Kg/d
Relative Dose 0.3 %

References

  1. AAP - American Academy of Pediatrics Committee on Drugs. Transfer of drugs and other chemicals into human milk. Pediatrics. 2001 Sep;108(3):776-89. Abstract Full text (link to original source) Full text (in our servers)
  2. Nielsen ST, Matheson I, Rasmussen JN, Skinnemoen K, Andrew E, Hafsahl G. Excretion of iohexol and metrizoate in human breast milk. Acta Radiol. 1987 Abstract

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