ألوبيرينول

Allopurinol and its metabolite oxypurinol decrease the level of uric acid in plasma and urine by inhibiting the xanthine oxidase enzyme. Indicated for the treatment of clinical manifestations of uric acid/urate deposits, such as gout or gouty lithiasis. It has been used in Chagas disease. Oral administration.

In a mother, allopurinol was excreted in breast milk in an insignificant amount, but the levels of allopurinol were elevated. ^{(Kamilli 1993 y 1991)}

No clinical or laboratory problems were observed in two infants whose mothers was taking allopurinol ^{(Thornley 1994, Kamilli 1993)}. The levels of allopurinol in the plasma of one infant were undetectable, but those of oxipurinol were almost at a therapeutic level. ^{(Kamilli 1993 y 1991)}

Allopurinol side effects are very rare and not serious. It can cause the appearance of rash. ^{(AEMPS 2020, AA Pharma 2010)}

American Academy of Pediatrics: medication usually compatible with breastfeeding ^{(AAP 2001)}. Recommendations for Drugs in the Eleventh WHO Model List of Essential Drugs: compatible with Breastfeeding. ^{(WHO 2002)}